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Serum levels of C1q/TNF-related protein-1 (CTRP-1) are closely associated with
coronary artery disease
#MMPMID27169633
Wang H
; Wang R
; Du D
; Li F
; Li Y
BMC Cardiovasc Disord
2016[May]; 16
(?): 92
PMID27169633
show ga
BACKGROUND: Complement C1q tumor necrosis factor related proteins (CTRPs) have
been proved to have diverse biological influences on cardiovascular system. CTRP
1 is a member of the CTRP superfamily, however, the relevance with coronary
artery disease (CAD) are seldom explored. This study was designed to investigate
the correlation between serum levels of CTRP 1 and CAD. METHODS: CTRP 1 levels of
150 CAD patients and 50 non-CAD subjects were determined by enzymelinked
immunosorbent assay. Further analysis of CTRP 1 levels in different stages and
lesion vessels of CAD were conducted. RESULTS: Serum levels of CTRP 1 in CAD
patients were significantly elevated, and it was increased with the severity of
CAD. CTRP 1 level in acute myocardial infarction group was much higher than that
in stable/unstable angina and non-CAD groups. And significant differences of CTRP
1 were also found between single-vessel disease and triple-vessel disease.
Multiple logistic regression analysis showed that CTRP 1 was an independent risk
factor of the occurrence of myocardial infarction. CONCLUSIONS: Increased serum
CTRP 1 levels were closely associated with the prevalence and severity of CAD, it
might be regarded as a marker for myocardial infarction.
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