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10.1186/s13058-016-0703-7 http://scihub22266oqcxt.onion/10.1186/s13058-016-0703-7 C4864897!4864897 !27169366     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27169366 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Breast+Cancer+Res 2016 ; 18 (1 ): 49 Nephropedia Template TP {{tp|p=27169366 |t=2016. Neutrophils drive accelerated tumor progression in the collagen-dense mammary tumor microenvironment |pdf=|usr=}}{{27169366 }} gab.com Text Neutrophils drive accelerated tumor progression in the collagen-dense mammary tumor microenvironment JO: Breast Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27169366 #FOAvip BACKGROUND: High mammographic density has been correlated with a 4-fold to 6-fold increased risk of developing breast cancer, and is associated with increased stromal deposition of extracellular matrix proteins, including collagen I. The molecular and cellular mechanisms responsible for high breast tissue density are not completely understood. METHODS: We previously described accelerated tumor formation and metastases in a transgenic mouse model of collagen-dense mammary tumors (type I collagen-?1 (Col1?1)(tm1Jae) and mouse mammary tumor virus - polyoma virus middle T antigen (MMTV-PyVT)) compared to wild-type mice. Using ELISA cytokine arrays and multi-color flow cytometry analysis, we studied cytokine signals and the non-malignant, immune cells in the collagen-dense tumor microenvironment that may promote accelerated tumor progression and metastasis. RESULTS: Collagen-dense tumors did not show any alteration in immune cell populations at late stages. The cytokine signals in the mammary tumor microenvironment were clearly different between wild-type and collagen-dense tumors. Cytokines associated with neutrophil signaling, such as granulocyte monocyte-colony stimulated factor (GM-CSF), were increased in collagen-dense tumors. Depleting neutrophils with anti-Ly6G (1A8) significantly reduced the number of tumors, and blocked metastasis in over 80 % of mice with collagen-dense tumors, but did not impact tumor growth or metastasis in wild-type mice. CONCLUSION: Our study suggests that tumor progression in a collagen-dense microenvironment is mechanistically different, with pro-tumor neutrophils, compared to a non-dense microenvironment. Twit Text FOAVip Neutrophils drive accelerated tumor progression in the collagen-dense mammary tumor microenvironment ????Breast Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27169366 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27169366 #FOAvip English Wikipedia <ref>{{Cite pmid|27169366 }}</ref> Neutrophils drive accelerated tumor progression in the collagen-dense mammary tumor microenvironment #MMPMID27169366 García-Mendoza MG ; Inman DR ; Ponik SM ; Jeffery JJ ; Sheerar DS ; Van Doorn RR ; Keely PJ Breast Cancer Res 2016[May]; 18 (1 ): 49 PMID27169366 show ga BACKGROUND: High mammographic density has been correlated with a 4-fold to 6-fold increased risk of developing breast cancer, and is associated with increased stromal deposition of extracellular matrix proteins, including collagen I. The molecular and cellular mechanisms responsible for high breast tissue density are not completely understood. METHODS: We previously described accelerated tumor formation and metastases in a transgenic mouse model of collagen-dense mammary tumors (type I collagen-?1 (Col1?1)(tm1Jae) and mouse mammary tumor virus - polyoma virus middle T antigen (MMTV-PyVT)) compared to wild-type mice. Using ELISA cytokine arrays and multi-color flow cytometry analysis, we studied cytokine signals and the non-malignant, immune cells in the collagen-dense tumor microenvironment that may promote accelerated tumor progression and metastasis. RESULTS: Collagen-dense tumors did not show any alteration in immune cell populations at late stages. The cytokine signals in the mammary tumor microenvironment were clearly different between wild-type and collagen-dense tumors. Cytokines associated with neutrophil signaling, such as granulocyte monocyte-colony stimulated factor (GM-CSF), were increased in collagen-dense tumors. Depleting neutrophils with anti-Ly6G (1A8) significantly reduced the number of tumors, and blocked metastasis in over 80 % of mice with collagen-dense tumors, but did not impact tumor growth or metastasis in wild-type mice. CONCLUSION: Our study suggests that tumor progression in a collagen-dense microenvironment is mechanistically different, with pro-tumor neutrophils, compared to a non-dense microenvironment. |*Tumor Microenvironment/immunology [MESH] |Animals [MESH] |Breast Neoplasms/diagnostic imaging/immunology/*metabolism/*pathology [MESH] |Collagen/genetics/*metabolism [MESH] |Cytokines/genetics/metabolism [MESH] |Disease Models, Animal [MESH] |Disease Progression [MESH] |Female [MESH] |Gene Expression [MESH] |Humans [MESH] |Lymphocytes, Tumor-Infiltrating/immunology/metabolism [MESH] |Mammary Neoplasms, Experimental [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Myeloid Cells/immunology/metabolism [MESH] |Neoplasm Metastasis [MESH] |Neutrophil Infiltration/immunology [MESH] |Neutrophils/immunology/*metabolism/*pathology [MESH] |Positron-Emission Tomography [MESH] |Spleen/pathology [MESH] |T-Lymphocyte Subsets/immunology/metabolism [MESH]Neutrophils drive accelerated tumor progression in the collagen-dense (epmc).pdf DeepDyve Pubget Overpricing