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10.1155/2016/2847232

http://scihub22266oqcxt.onion/10.1155/2016/2847232
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suck abstract from ncbi


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pmid27239100      Mediators+Inflamm 2016 ; 2016 (ä): ä
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  • Administration of Myelin Basic Protein Peptides Encapsulated in Mannosylated Liposomes Normalizes Level of Serum TNF-? and IL-2 and Chemoattractants CCL2 and CCL4 in Multiple Sclerosis Patients #MMPMID27239100
  • Lomakin Y; Belogurov A; Glagoleva I; Stepanov A; Zakharov K; Okunola J; Smirnov I; Genkin D; Gabibov A
  • Mediators Inflamm 2016[]; 2016 (ä): ä PMID27239100show ga
  • We have previously shown that immunodominant MBP peptides encapsulated in mannosylated liposomes (Xemys) effectively suppressed experimental allergic encephalomyelitis (EAE). Within the frames of the successfully completed phase I clinical trial, we investigated changes in the serum cytokine profile after Xemys administration in MS patients. We observed a statistically significant decrease of MCP-1/CCL2, MIP-1?/CCL4, IL-7, and IL-2 at the time of study completion. In contrast, the serum levels of TNF-? were remarkably elevated. Our data suggest that the administration of Xemys leads to a normalization of cytokine status in MS patients to values commonly reported for healthy subjects. These data are an important contribution for the upcoming Xemys clinical trials.
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