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2016 ; 2016
(ä): 2847232
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Administration of Myelin Basic Protein Peptides Encapsulated in Mannosylated
Liposomes Normalizes Level of Serum TNF-? and IL-2 and Chemoattractants CCL2 and
CCL4 in Multiple Sclerosis Patients
#MMPMID27239100
Lomakin Y
; Belogurov A Jr
; Glagoleva I
; Stepanov A
; Zakharov K
; Okunola J
; Smirnov I
; Genkin D
; Gabibov A
Mediators Inflamm
2016[]; 2016
(ä): 2847232
PMID27239100
show ga
We have previously shown that immunodominant MBP peptides encapsulated in
mannosylated liposomes (Xemys) effectively suppressed experimental allergic
encephalomyelitis (EAE). Within the frames of the successfully completed phase I
clinical trial, we investigated changes in the serum cytokine profile after Xemys
administration in MS patients. We observed a statistically significant decrease
of MCP-1/CCL2, MIP-1?/CCL4, IL-7, and IL-2 at the time of study completion. In
contrast, the serum levels of TNF-? were remarkably elevated. Our data suggest
that the administration of Xemys leads to a normalization of cytokine status in
MS patients to values commonly reported for healthy subjects. These data are an
important contribution for the upcoming Xemys clinical trials.