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10.1016/j.cell.2015.08.016 http://scihub22266oqcxt.onion/10.1016/j.cell.2015.08.016 C4864363!4864363!26321679     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2015 ; 162 (6): 1229-41 Nephropedia Template TP {{tp|p=26321679|t=2015. Metabolic competition in the tumor microenvironment is a driver of cancer progression |pdf=|usr=}}{{26321679}} gab.com Text Metabolic competition in the tumor microenvironment is a driver of cancer progression JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=26321679 #FOAvip Failure of T cells to protect against cancer is thought to result from lack of antigen recognition, chronic activation, and/or suppression by other cells. Using a mouse sarcoma model, we show that glucose consumption by tumors metabolically restricts T cells, leading to their dampened mTOR activity, glycolytic capacity, and IFN-? production, thereby allowing tumor progression. We show that enhancing glycolysis in an antigenic ?regressor? tumor is sufficient to override the protective ability of T cells to control tumor growth. We also show that checkpoint blockade antibodies against CTLA-4, PD-1, and PD-L1, which are used clinically, restore glucose in tumors, permitting T cell glycolysis and IFN-? production. Furthermore, we found that blocking PD-L1 directly on tumors dampens glycolysis by inhibiting mTOR activity and decreasing expression of glycolysis enzymes, reflecting a role for PD-L1 in tumor glucose utilization. Our results establish that tumor-imposed metabolic restrictions can mediate T cell hyporesponsiveness during cancer. Twit Text FOAVip Metabolic competition in the tumor microenvironment is a driver of cancer progression ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=26321679 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26321679 #FOAvip English Wikipedia <ref>{{Cite pmid|26321679}}</ref> Metabolic competition in the tumor microenvironment is a driver of cancer progression #MMPMID26321679 Chang CH; Qiu J; O?Sullivan D; Buck MD; Noguchi T; Curtis JD; Chen Q; Gindin M; Gubin MM; van der Windt GJ; Tonc E; Schreiber RD; Pearce EJ; Pearce EL Cell 2015[Sep]; 162 (6): 1229-41 PMID26321679show ga Failure of T cells to protect against cancer is thought to result from lack of antigen recognition, chronic activation, and/or suppression by other cells. Using a mouse sarcoma model, we show that glucose consumption by tumors metabolically restricts T cells, leading to their dampened mTOR activity, glycolytic capacity, and IFN-? production, thereby allowing tumor progression. We show that enhancing glycolysis in an antigenic ?regressor? tumor is sufficient to override the protective ability of T cells to control tumor growth. We also show that checkpoint blockade antibodies against CTLA-4, PD-1, and PD-L1, which are used clinically, restore glucose in tumors, permitting T cell glycolysis and IFN-? production. Furthermore, we found that blocking PD-L1 directly on tumors dampens glycolysis by inhibiting mTOR activity and decreasing expression of glycolysis enzymes, reflecting a role for PD-L1 in tumor glucose utilization. Our results establish that tumor-imposed metabolic restrictions can mediate T cell hyporesponsiveness during cancer. äMetabolic competition in the tumor microenvironment is a driver of can(epmc).pdf DeepDyve Pubget Overpricing