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10.1002/cam4.711 http://scihub22266oqcxt.onion/10.1002/cam4.711 C4864275!4864275 !27139420     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27139420 &cmd=llinks): Failed to open stream: HTTP request failed! 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Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway |pdf=|usr=}}{{27139420 }} gab.com Text Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway JO: Cancer Med http://www.kidney.de/pget.php?&tw=1&pmid=27139420 #FOAvip Fatty acid synthase (Fasn) is the key metabolic enzyme that accounts for the terminal catalytic step in fatty acid synthesis, which is hyperactivated in various tumors. In this study, we depicted that Fasn expression was elevated in human colorectal cancer (CRC), which accordingly led to lymphatic and distant metastasis and a more advanced clinical phenotype. Genetic perturbations demonstrated that knocking down Fasn inhibited cell migration and invasion both in SW480 and HT29 CRC cell lines. Further mechanical exploration revealed that Fasn knockdown could attenuate Wnt signaling pathway via downregulating distinctive genes, namely Wnt5a, Wnt5b, Fzd2, which at least partly contributed to the decrease in metastasis. Clinical evidence verified a positive correlation between Fasn expression and Wnt signal marker gene expression in a cohort of 43 CRC patients. In conclusion, we shed light on metabolic switches took place during CRC carcinogenesis, among which Fasn is a critical factor and a potential therapeutic target. Twit Text FOAVip Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway ????Cancer Med http://www.kidney.de/pget.php?&tw=1&pmid=27139420 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27139420 #FOAvip English Wikipedia <ref>{{Cite pmid|27139420 }}</ref> Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway #MMPMID27139420 Wang H ; Xi Q ; Wu G Cancer Med 2016[Jul]; 5 (7 ): 1599-606 PMID27139420 show ga Fatty acid synthase (Fasn) is the key metabolic enzyme that accounts for the terminal catalytic step in fatty acid synthesis, which is hyperactivated in various tumors. In this study, we depicted that Fasn expression was elevated in human colorectal cancer (CRC), which accordingly led to lymphatic and distant metastasis and a more advanced clinical phenotype. Genetic perturbations demonstrated that knocking down Fasn inhibited cell migration and invasion both in SW480 and HT29 CRC cell lines. Further mechanical exploration revealed that Fasn knockdown could attenuate Wnt signaling pathway via downregulating distinctive genes, namely Wnt5a, Wnt5b, Fzd2, which at least partly contributed to the decrease in metastasis. Clinical evidence verified a positive correlation between Fasn expression and Wnt signal marker gene expression in a cohort of 43 CRC patients. In conclusion, we shed light on metabolic switches took place during CRC carcinogenesis, among which Fasn is a critical factor and a potential therapeutic target. |*Wnt Signaling Pathway [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Cell Line, Tumor [MESH] |Cell Movement [MESH] |Colorectal Neoplasms/genetics/*metabolism/mortality/*pathology [MESH] |Fatty Acid Synthase, Type I/genetics/metabolism [MESH] |Fatty Acid Synthases/genetics/*metabolism [MESH] |Female [MESH] |Gene Expression [MESH] |Gene Knockdown Techniques [MESH] |Humans [MESH] |Male [MESH] |Middle Aged [MESH] |Neoplasm Invasiveness [MESH] |Neoplasm Metastasis [MESH] |Neoplasm Staging [MESH]Fatty acid synthase regulates invasion and metastasis of colorectal ca(epmc).pdf DeepDyve Pubget Overpricing