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10.1016/j.cub.2016.03.037 http://scihub22266oqcxt.onion/10.1016/j.cub.2016.03.037 C4864120!4864120!27032491     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27032491&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Biol 2016 ; 26 (9): 1241-7 Nephropedia Template TP {{tp|p=27032491|t=2016. The combined landscape of Denisovan and Neanderthal ancestry in present-day humans |pdf=|usr=}}{{27032491}} gab.com Text The combined landscape of Denisovan and Neanderthal ancestry in present-day humans JO: Curr Biol http://www.kidney.de/pget.php?&tw=1&pmid=27032491 #FOAvip Some present-day humans derive up to ~5% [1] of their ancestry from archaic Denisovans, an even larger proportion than the ~2% from Neanderthals [2]. We developed methods that can disambiguate the locations of segments of Denisovan and Neanderthal ancestry in present-day humans, and applied them to 257 high coverage genomes from 120 diverse populations among which were 20 individual Oceanians with high Denisovan ancestry [3]. In Oceanians, the average size of Denisovan fragments is larger than Neanderthal fragments, implying a more recent average date of Denisovan admixture in the history of these populations (P=0.00004). We document more Denisovan ancestry in South Asia than is expected based on existing models of history, reflecting a previously undocumented mixture related to archaic humans (P=0.0013). Denisovan ancestry just like Neanderthal ancestry has been deleterious on a modern human genetic background, as reflected by its depletion near genes. Finally, the reduction of both archaic ancestries is especially pronounced on chromosome X and near genes more highly expressed in testes than other tissues (P=1.2×10?7 to 3.2×10?7 for Denisovan and 2.2×10?3 to 2.9×10?3 for Neanderthal ancestry even after controlling for differences in level of selective constraint across gene classes). This suggests that reduced male fertility may be a general feature of mixtures of human populations diverged by >500,000 years. Twit Text FOAVip The combined landscape of Denisovan and Neanderthal ancestry in present-day humans ????Curr Biol http://www.kidney.de/pget.php?&tw=1&pmid=27032491 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27032491 #FOAvip English Wikipedia <ref>{{Cite pmid|27032491}}</ref> The combined landscape of Denisovan and Neanderthal ancestry in present-day humans #MMPMID27032491 Sankararaman S; Mallick S; Patterson N; Reich D Curr Biol 2016[May]; 26 (9): 1241-7 PMID27032491show ga Some present-day humans derive up to ~5% [1] of their ancestry from archaic Denisovans, an even larger proportion than the ~2% from Neanderthals [2]. We developed methods that can disambiguate the locations of segments of Denisovan and Neanderthal ancestry in present-day humans, and applied them to 257 high coverage genomes from 120 diverse populations among which were 20 individual Oceanians with high Denisovan ancestry [3]. In Oceanians, the average size of Denisovan fragments is larger than Neanderthal fragments, implying a more recent average date of Denisovan admixture in the history of these populations (P=0.00004). We document more Denisovan ancestry in South Asia than is expected based on existing models of history, reflecting a previously undocumented mixture related to archaic humans (P=0.0013). Denisovan ancestry just like Neanderthal ancestry has been deleterious on a modern human genetic background, as reflected by its depletion near genes. Finally, the reduction of both archaic ancestries is especially pronounced on chromosome X and near genes more highly expressed in testes than other tissues (P=1.2×10?7 to 3.2×10?7 for Denisovan and 2.2×10?3 to 2.9×10?3 for Neanderthal ancestry even after controlling for differences in level of selective constraint across gene classes). This suggests that reduced male fertility may be a general feature of mixtures of human populations diverged by >500,000 years. äThe combined landscape of Denisovan and Neanderthal ancestry in presen(epmc).pdf DeepDyve Pubget Overpricing