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10.3109/10409238.2015.1085826 http://scihub22266oqcxt.onion/10.3109/10409238.2015.1085826 C4864032!4864032 !26362261     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26362261 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Crit+Rev+Biochem+Mol+Biol 2015 ; 50 (6 ): 477-88 Nephropedia Template TP {{tp|p=26362261 |t=2015. A bacterial toxin and a nonenveloped virus hijack ER-to-cytosol membrane translocation pathways to cause disease |pdf=|usr=}}{{26362261 }} gab.com Text A bacterial toxin and a nonenveloped virus hijack ER-to-cytosol membrane translocation pathways to cause disease JO: Crit Rev Biochem Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=26362261 #FOAvip A dedicated network of cellular factors ensures that proteins translocated into the endoplasmic reticulum (ER) are folded correctly before they exit this compartment en route to other cellular destinations or for secretion. When proteins misfold, selective ER-resident enzymes and chaperones are recruited to rectify the protein-misfolding problem in order to maintain cellular proteostasis. However, when a protein becomes terminally misfolded, it is ejected into the cytosol and degraded by the proteasome via a pathway called ER-associated degradation (ERAD). Strikingly, toxins and viruses can hijack elements of the ERAD pathway to access the host cytosol and cause infection. This review focuses on emerging data illuminating the molecular mechanisms by which these toxic agents co-opt the ER-to-cytosol translocation process to cause disease. Twit Text FOAVip A bacterial toxin and a nonenveloped virus hijack ER-to-cytosol membrane translocation pathways to cause disease ????Crit Rev Biochem Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=26362261 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26362261 #FOAvip English Wikipedia <ref>{{Cite pmid|26362261 }}</ref> A bacterial toxin and a nonenveloped virus hijack ER-to-cytosol membrane translocation pathways to cause disease #MMPMID26362261 He K ; Ravindran MS ; Tsai B Crit Rev Biochem Mol Biol 2015[]; 50 (6 ): 477-88 PMID26362261 show ga A dedicated network of cellular factors ensures that proteins translocated into the endoplasmic reticulum (ER) are folded correctly before they exit this compartment en route to other cellular destinations or for secretion. When proteins misfold, selective ER-resident enzymes and chaperones are recruited to rectify the protein-misfolding problem in order to maintain cellular proteostasis. However, when a protein becomes terminally misfolded, it is ejected into the cytosol and degraded by the proteasome via a pathway called ER-associated degradation (ERAD). Strikingly, toxins and viruses can hijack elements of the ERAD pathway to access the host cytosol and cause infection. This review focuses on emerging data illuminating the molecular mechanisms by which these toxic agents co-opt the ER-to-cytosol translocation process to cause disease. |*Bacterial Physiological Phenomena [MESH] |*Endoplasmic Reticulum-Associated Degradation [MESH] |*Host-Pathogen Interactions [MESH] |Animals [MESH] |Bacterial Infections/*metabolism [MESH] |Bacterial Toxins/*metabolism [MESH] |Cytosol/metabolism/microbiology/virology [MESH] |Endoplasmic Reticulum/metabolism/microbiology/virology [MESH] |Humans [MESH] |Polyomavirus Infections/*metabolism [MESH] |Polyomavirus/*physiology [MESH]A bacterial toxin and a nonenveloped virus hijack ER-to-cytosol membra(epmc).pdf DeepDyve Pubget Overpricing