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10.1172/jci.insight.85608 http://scihub22266oqcxt.onion/10.1172/jci.insight.85608 C4864003!4864003!27182558     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight ä ; 1 (6): ä Nephropedia Template TP {{tp|p=27182558|t=ä. Alk5 inhibition increases delivery of macromolecular and protein-bound contrast agents to tumors |pdf=|usr=}}{{27182558}} gab.com Text Alk5 inhibition increases delivery of macromolecular and protein-bound contrast agents to tumors JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=27182558 #FOAvip Limited transendothelial permeability across tumor microvessels represents a significant bottleneck in the development of tumor-specific diagnostic agents and theranostic drugs. Here, we show an approach to increase transendothelial permeability of macromolecular and nanoparticle-based contrast agents via inhibition of the type I TGF-? receptor, activin-like kinase 5 (Alk5), in tumors. Alk5 inhibition significantly increased tumor contrast agent delivery and enhancement on imaging studies, while healthy organs remained relatively unaffected. Imaging data correlated with significantly decreased tumor interstitial fluid pressure, while tumor vascular density remained unchanged. This immediately clinically translatable concept involving Alk5 inhibitor pretreatment prior to an imaging study could be leveraged for improved tumor delivery of macromolecular and nanoparticle-based imaging probes and, thereby, facilitate development of more sensitive imaging tests for cancer diagnosis, enhanced tumor characterization, and personalized, image-guided therapies. Twit Text FOAVip Alk5 inhibition increases delivery of macromolecular and protein-bound contrast agents to tumors ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=27182558 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27182558 #FOAvip English Wikipedia <ref>{{Cite pmid|27182558}}</ref> Alk5 inhibition increases delivery of macromolecular and protein-bound contrast agents to tumors #MMPMID27182558 Daldrup-Link HE; Mohanty S; Ansari C; Lenkov O; Shaw A; Ito K; Hong SH; Hoffmann M; Pisani L; Boudreau N; Gambhir SS; Coussens LM JCI Insight ä[]; 1 (6): ä PMID27182558show ga Limited transendothelial permeability across tumor microvessels represents a significant bottleneck in the development of tumor-specific diagnostic agents and theranostic drugs. Here, we show an approach to increase transendothelial permeability of macromolecular and nanoparticle-based contrast agents via inhibition of the type I TGF-? receptor, activin-like kinase 5 (Alk5), in tumors. Alk5 inhibition significantly increased tumor contrast agent delivery and enhancement on imaging studies, while healthy organs remained relatively unaffected. Imaging data correlated with significantly decreased tumor interstitial fluid pressure, while tumor vascular density remained unchanged. This immediately clinically translatable concept involving Alk5 inhibitor pretreatment prior to an imaging study could be leveraged for improved tumor delivery of macromolecular and nanoparticle-based imaging probes and, thereby, facilitate development of more sensitive imaging tests for cancer diagnosis, enhanced tumor characterization, and personalized, image-guided therapies. äAlk5 inhibition increases delivery of macromolecular and protein-bound(epmc).pdf DeepDyve Pubget Overpricing