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2014 ; 297
(9
): 1758-69
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The role of mechanotransduction on vascular smooth muscle myocytes corrected
cytoskeleton and contractile function
#MMPMID25125187
Ye GJ
; Nesmith AP
; Parker KK
Anat Rec (Hoboken)
2014[Sep]; 297
(9
): 1758-69
PMID25125187
show ga
Smooth muscle (SM) exhibits a highly organized structural hierarchy that extends
over multiple spatial scales to perform a wide range of functions at the
cellular, tissue, and organ levels. Early efforts primarily focused on
understanding vascular SM (VSM) function through biochemical signaling. However,
accumulating evidence suggests that mechanotransduction, the process through
which cells convert mechanical stimuli into biochemical cues, is requisite for
regulating contractility. Cytoskeletal proteins that comprise the extracellular,
intercellular, and intracellular domains are mechanosensitive and can remodel
their structure and function in response to external mechanical cues.
Pathological stimuli such as malignant hypertension can act through the same
mechanotransductive pathways to induce maladaptive remodeling, leading to changes
in cellular shape and loss of contractile function. In both health and disease,
the cytoskeletal architecture integrates the mechanical stimuli and mediates
structural and functional remodeling in the VSM.