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10.1097/MD.0000000000003595 http://scihub22266oqcxt.onion/10.1097/MD.0000000000003595 C4863807!4863807 !27149490     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27149490 &cmd=llinks): Failed to open stream: HTTP request failed! 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Plasmapheresis Is Associated With Better Renal Outcomes in Lupus Nephritis Patients With Thrombotic Microangiopathy: A Case Series Study |pdf=|usr=}}{{27149490 }} gab.com Text Plasmapheresis Is Associated With Better Renal Outcomes in Lupus Nephritis Patients With Thrombotic Microangiopathy: A Case Series Study JO: Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=27149490 #FOAvip The aim of this study was to evaluate the efficacy of plasmapheresis in patients with lupus nephritis-combined thrombotic microangiopathy (TMA) in a Chinese cohort.Clinical and therapeutic data of patients with lupus nephritis-combined TMA were collected retrospectively. A comparison between those with and without plasmapheresis was performed.Seventy patients with renal biopsy-proven TMA in lupus nephritis were treated with conventional combined corticosteroid and immunosuppressive agents as induction therapy, 9 of the 70 patients received additional plasmapheresis. The plasmapheresis group presented with more severe SLE and renal activity indices, including a significant higher ratio of neurologic disorder (P?=?0.025), lower level of platelet count (P?=?0.009), higher value of serum creatinine (P?=?0.038), higher percentage of anti-cardiolipin antibodies positive (P?=?0.001), and higher Systemic Lupus Erythematosus Disease Activity Index scores (P?=?0.012), than that of the nonplasmapheresis group. However, the plasmapheresis group had a significant higher rate of remission and a lower ratio of treatment failure than that of the nonplasmapheresis group (P?=?0.03). As the baseline data were significantly different between the 2 groups, the propensity score match was further designed to avoid retrospective bias. After re-analysis, the plasmapheresis group still had a significant higher rate of remission and a lower ratio of treatment failure than that of the nonplasmapheresis group (P?=?0.018). More importantly, the plasmapheresis group had significant less composite endpoints than that of the nonplasmapheresis group (P?=?0.005).Our study suggested that additional plasmapheresis on conventional induction therapy may benefit patients with lupus nephritis-combined TMA, which warrants further explorations. Twit Text FOAVip Plasmapheresis Is Associated With Better Renal Outcomes in Lupus Nephritis Patients With Thrombotic Microangiopathy: A Case Series Study ????Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=27149490 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27149490 #FOAvip English Wikipedia <ref>{{Cite pmid|27149490 }}</ref> Plasmapheresis Is Associated With Better Renal Outcomes in Lupus Nephritis Patients With Thrombotic Microangiopathy: A Case Series Study #MMPMID27149490 Li QY ; Yu F ; Zhou FD ; Zhao MH Medicine (Baltimore) 2016[May]; 95 (18 ): e3595 PMID27149490 show ga The aim of this study was to evaluate the efficacy of plasmapheresis in patients with lupus nephritis-combined thrombotic microangiopathy (TMA) in a Chinese cohort.Clinical and therapeutic data of patients with lupus nephritis-combined TMA were collected retrospectively. A comparison between those with and without plasmapheresis was performed.Seventy patients with renal biopsy-proven TMA in lupus nephritis were treated with conventional combined corticosteroid and immunosuppressive agents as induction therapy, 9 of the 70 patients received additional plasmapheresis. The plasmapheresis group presented with more severe SLE and renal activity indices, including a significant higher ratio of neurologic disorder (P?=?0.025), lower level of platelet count (P?=?0.009), higher value of serum creatinine (P?=?0.038), higher percentage of anti-cardiolipin antibodies positive (P?=?0.001), and higher Systemic Lupus Erythematosus Disease Activity Index scores (P?=?0.012), than that of the nonplasmapheresis group. However, the plasmapheresis group had a significant higher rate of remission and a lower ratio of treatment failure than that of the nonplasmapheresis group (P?=?0.03). As the baseline data were significantly different between the 2 groups, the propensity score match was further designed to avoid retrospective bias. After re-analysis, the plasmapheresis group still had a significant higher rate of remission and a lower ratio of treatment failure than that of the nonplasmapheresis group (P?=?0.018). More importantly, the plasmapheresis group had significant less composite endpoints than that of the nonplasmapheresis group (P?=?0.005).Our study suggested that additional plasmapheresis on conventional induction therapy may benefit patients with lupus nephritis-combined TMA, which warrants further explorations. |*Plasmapheresis [MESH] |Adolescent [MESH] |Adrenal Cortex Hormones/therapeutic use [MESH] |Adult [MESH] |Combined Modality Therapy [MESH] |Drug Therapy, Combination [MESH] |Female [MESH] |Humans [MESH] |Immunosuppressive Agents/therapeutic use [MESH] |Lupus Nephritis/complications/*therapy [MESH] |Male [MESH] |Middle Aged [MESH] |Remission Induction/methods [MESH] |Retrospective Studies [MESH] |Severity of Illness Index [MESH] |Thrombotic Microangiopathies/complications/*therapy [MESH] |Treatment Failure [MESH]Plasmapheresis Is Associated With Better Renal Outcomes in Lupus Nephr(epmc).pdf DeepDyve Pubget Overpricing