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10.1101/gad.279448.116

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C4863736!4863736!27125673
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suck abstract from ncbi


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pmid27125673      Genes+Dev 2016 ; 30 (9): 1047-57
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  • Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides #MMPMID27125673
  • Artan M; Jeong DE; Lee D; Kim YI; Son HG; Husain Z; Kim J; Altintas O; Kim K; Alcedo J; Lee SJV
  • Genes Dev 2016[May]; 30 (9): 1047-57 PMID27125673show ga
  • How sensory neurons coordinate organismal aging in response to changes in environmental signals remains elusive. Artan et al. show that a subset of sensory neurons shortens C. elegans? life span by differentially regulating the expression of a specific insulin-like peptide (ILP), INS-6. INS-6 in turn relays the longevity signals to nonneuronal tissues by decreasing the activity of the transcription factor DAF-16/FOXO.
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