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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Genes+Dev 2016 ; 30 (9): 1034-46 Nephropedia Template TP
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Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1?/ERR? #MMPMID27151976
Yan M; Audet-Walsh É; Manteghi S; Dufour CR; Walker B; Baba M; St-Pierre J; Gigučre V; Pause A
Genes Dev 2016[May]; 30 (9): 1034-46 PMID27151976show ga
In this study, Yan et al. use a mouse model to show that loss of folliculin (FLCN), which forms a repressor complex with AMPK, results in a complete metabolic reprogramming of adipose tissues, resulting in enhanced oxidative metabolism. The results provide new insight into the role of FLCN as a negative regulator of mitochondrial function as well as the pathways involved in the browning of white adipocytes and the activity of brown fat.