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10.1101/gad.281410.116 http://scihub22266oqcxt.onion/10.1101/gad.281410.116 C4863735!4863735 !27151976     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27151976 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genes+Dev 2016 ; 30 (9 ): 1034-46 Nephropedia Template TP {{tp|p=27151976 |t=2016. Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1?/ERR? |pdf=|usr=}}{{27151976 }} gab.com Text Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1 /ERR JO: Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=27151976 #FOAvip The tumor suppressor folliculin (FLCN) forms a repressor complex with AMP-activated protein kinase (AMPK). Given that AMPK is a master regulator of cellular energy homeostasis, we generated an adipose-specific Flcn (Adipoq-FLCN) knockout mouse model to investigate the role of FLCN in energy metabolism. We show that loss of FLCN results in a complete metabolic reprogramming of adipose tissues, resulting in enhanced oxidative metabolism. Adipoq-FLCN knockout mice exhibit increased energy expenditure and are protected from high-fat diet (HFD)-induced obesity. Importantly, FLCN ablation leads to chronic hyperactivation of AMPK, which in turns induces and activates two key transcriptional regulators of cellular metabolism, proliferator-activated receptor ? (PPAR?) coactivator-1? (PGC-1?) and estrogen-related receptor ? (ERR?). Together, the AMPK/PGC-1?/ERR? molecular axis positively modulates the expression of metabolic genes to promote mitochondrial biogenesis and activity. In addition, mitochondrial uncoupling proteins as well as other markers of brown fat are up-regulated in both white and brown FLCN-null adipose tissues, underlying the increased resistance of Adipoq-FLCN knockout mice to cold exposure. These findings identify a key role of FLCN as a negative regulator of mitochondrial function and identify a novel molecular pathway involved in the browning of white adipocytes and the activity of brown fat. Twit Text FOAVip Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1 /ERR ????Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=27151976 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27151976 #FOAvip English Wikipedia <ref>{{Cite pmid|27151976 }}</ref> Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1?/ERR? #MMPMID27151976 Yan M ; Audet-Walsh É ; Manteghi S ; Dufour CR ; Walker B ; Baba M ; St-Pierre J ; Gigučre V ; Pause A Genes Dev 2016[May]; 30 (9 ): 1034-46 PMID27151976 show ga The tumor suppressor folliculin (FLCN) forms a repressor complex with AMP-activated protein kinase (AMPK). Given that AMPK is a master regulator of cellular energy homeostasis, we generated an adipose-specific Flcn (Adipoq-FLCN) knockout mouse model to investigate the role of FLCN in energy metabolism. We show that loss of FLCN results in a complete metabolic reprogramming of adipose tissues, resulting in enhanced oxidative metabolism. Adipoq-FLCN knockout mice exhibit increased energy expenditure and are protected from high-fat diet (HFD)-induced obesity. Importantly, FLCN ablation leads to chronic hyperactivation of AMPK, which in turns induces and activates two key transcriptional regulators of cellular metabolism, proliferator-activated receptor ? (PPAR?) coactivator-1? (PGC-1?) and estrogen-related receptor ? (ERR?). Together, the AMPK/PGC-1?/ERR? molecular axis positively modulates the expression of metabolic genes to promote mitochondrial biogenesis and activity. In addition, mitochondrial uncoupling proteins as well as other markers of brown fat are up-regulated in both white and brown FLCN-null adipose tissues, underlying the increased resistance of Adipoq-FLCN knockout mice to cold exposure. These findings identify a key role of FLCN as a negative regulator of mitochondrial function and identify a novel molecular pathway involved in the browning of white adipocytes and the activity of brown fat. |AMP-Activated Protein Kinases/genetics [MESH] |Adipose Tissue, Beige/*metabolism [MESH] |Animals [MESH] |Cold Temperature [MESH] |ERRalpha Estrogen-Related Receptor [MESH] |Energy Metabolism/*genetics [MESH] |Enzyme Activation/genetics [MESH] |Gene Expression Regulation/genetics [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Obesity/enzymology/genetics [MESH] |Oxidation-Reduction [MESH] |Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/*metabolism [MESH] |Proto-Oncogene Proteins/*genetics/metabolism [MESH] |Receptors, Estrogen/genetics/*metabolism [MESH] |Signal Transduction [MESH]Chronic AMPK activation via loss of FLCN induces functional beige adip(epmc).pdf DeepDyve Pubget Overpricing