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10.1126/scisignal.aaa5622 http://scihub22266oqcxt.onion/10.1126/scisignal.aaa5622 C4863716!4863716!26038600     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Signal 2015 ; 8 (379): ra55 Nephropedia Template TP {{tp|p=26038600|t=2015. The role of ciliary trafficking in Hedgehog receptor signaling |pdf=|usr=}}{{26038600}} gab.com Text The role of ciliary trafficking in Hedgehog receptor signaling JO: Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=26038600 #FOAvip Defects in the biogenesis of or transport through primary cilia affect Hedgehog protein signaling, and many Hedgehog pathway components traffic through or accumulate in cilia. The Hedgehog receptor, Patched, negatively regulates the activity and ciliary accumulation of Smoothened, a seven transmembrane protein that is essential for transducing the Hedgehog signal. We found that this negative regulation of Smoothened required the ciliary localization of Patched, as specified either by its own cytoplasmic tail or by provision of heterologous ciliary localization signals. Surprisingly, given that Hedgehog binding promotes the exit of Patched from the cilium, we observed that an altered form of Patched that is retained in the cilium nevertheless responded to Hedgehog, resulting in Smoothened activation. Our results indicate that, whereas ciliary localization of Patched is essential for suppression of Smoothened activation, the primary event enabling Smoothened activation is binding of Hedgehog to Patched, and Patched ciliary removal is secondary. Twit Text FOAVip The role of ciliary trafficking in Hedgehog receptor signaling ????Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=26038600 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26038600 #FOAvip English Wikipedia <ref>{{Cite pmid|26038600}}</ref> The role of ciliary trafficking in Hedgehog receptor signaling #MMPMID26038600 Kim J; Hsia EYC; Brigui A; Plessis A; Beachy PA; Zheng X Sci Signal 2015[Jun]; 8 (379): ra55 PMID26038600show ga Defects in the biogenesis of or transport through primary cilia affect Hedgehog protein signaling, and many Hedgehog pathway components traffic through or accumulate in cilia. The Hedgehog receptor, Patched, negatively regulates the activity and ciliary accumulation of Smoothened, a seven transmembrane protein that is essential for transducing the Hedgehog signal. We found that this negative regulation of Smoothened required the ciliary localization of Patched, as specified either by its own cytoplasmic tail or by provision of heterologous ciliary localization signals. Surprisingly, given that Hedgehog binding promotes the exit of Patched from the cilium, we observed that an altered form of Patched that is retained in the cilium nevertheless responded to Hedgehog, resulting in Smoothened activation. Our results indicate that, whereas ciliary localization of Patched is essential for suppression of Smoothened activation, the primary event enabling Smoothened activation is binding of Hedgehog to Patched, and Patched ciliary removal is secondary. äThe role of ciliary trafficking in Hedgehog receptor signaling (epmc).pdf DeepDyve Pubget Overpricing