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2015 ; 10
(4
): 273-80
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Sex Differences in the Presentation, Diagnosis, and Management of Acute Coronary
Syndromes: Findings From the Kerala-India ACS Registry
#MMPMID26410401
Patel A
; Vishwanathan S
; Nair T
; Bahuleyan CG
; Jayaprakash VL
; Baldridge A
; Huffman MD
; Prabhakaran D
; Mohanan PP
Glob Heart
2015[Dec]; 10
(4
): 273-80
PMID26410401
show ga
BACKGROUND: Previous literature from high-income countries has repeatedly shown
sex differences in the presentation, diagnosis, and management of acute coronary
syndromes (ACS), with women having atypical presentations and undergoing less
aggressive diagnostic and therapeutic measures. However, much less data exist
evaluating sex differences in ACS in India. OBJECTIVES: This study sought to
evaluate sex differences in the diagnosis, management, and treatment of patients
with ACS in Kerala, India. METHODS: The Kerala ACS Registry collected data from
25,748 consecutive ACS admissions (19,923 men and 5,825 women) from 125 hospitals
in the Indian state of Kerala from 2007 to 2009. This study evaluated the
association between sex differences in presentation, in-hospital management, and
discharge care with in-hospital mortality and in-hospital major adverse
cardiovascular events (defined as death, reinfarction, stroke, heart failure, or
cardiogenic shock). RESULTS: Women with ACS were older than men with ACS (64 vs.
59, p < 0.001) and were more likely to have a history of previous myocardial
infarction (16% vs. 14%, p < 0.001). Inpatient diagnostics and management and
discharge care were similar between sexes. No significant differences between men
and women in the outcome of death (odds ratio [OR]: 1.05, 95% confidence interval
[CI]: 0.80 to 1.38) or in the composite outcome of death, reinfarction, stroke,
heart failure, or cardiogenic shock (OR: 0.99, 95% CI: 0.79 to 1.25) were seen
after adjustment for possible confounding factors. CONCLUSIONS: In Kerala, even
though women with ACS were older and more likely to have previous myocardial
infarction, there were no significant differences in in-hospital and discharge
management, in-hospital mortality, or major adverse cardiovascular events between
sexes. Whether these results apply to other parts of India or acute presentations
of other chronic diseases in low- and middle-income countries warrants further
study.