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10.4103/2277-9175.180990 http://scihub22266oqcxt.onion/10.4103/2277-9175.180990 C4863408!4863408!27195251     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27195251&cmd=llinks): Failed to open stream: HTTP request failed! 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Interaction of central Angiotensin II and estrogen on systolic blood pressure in female DOCA-salt treated rats |pdf=|usr=}}{{27195251}} gab.com Text Interaction of central Angiotensin II and estrogen on systolic blood pressure in female DOCA-salt treated rats JO: Adv Biomed Res http://www.kidney.de/pget.php?&tw=1&pmid=27195251 #FOAvip Background:: There is a probable interaction of central angiotensin II (Ang II) and estrogen (Est) on blood pressure in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Therefore, in the present study, the interaction between Ang II and Est in ovariectomized (Ovx) and Sham rats that were treated with DOCA- salt was evaluated. Materials and Methods:: The female rats were divided into 10 groups as follows: Sham, Ovx, Sham-DOCA, Ovx-DOCA, Sham-DOCA-estrogen (E), Ovx DOCA-E, Sham-DOCA-losartan (L), Ovx-DOCA-L, Sham?DOCA-L-E, and Ovx-DOCA-L-E. The Est groups received estradiol valerate (2 mg/kg; daily; subcutaneously (s.c)) for four weeks. Following that, several doses of Ang II (0.5, 5, 50, 500, 5000 ng/5 ?l) were injected via the intracerebroventricular (i.c.v) route and the changes in systolic blood pressure (SBP) were evaluated. In the losartan groups, 200 ?g losartan was injected (i.c.v) 15 minutes after the Ang II injection and the blood pressure was recorded. Treatment by DOCA was performed by removal of one kidney, injection of DOCA (45 mg/kg i.p), and adding of sodium chloride (NaCl) (1%) and potassium chloride (KCl) (0.1%) in the drinking water. Results:: The SBP was increased by Ang II and this effect in DOCA-salt treated rat was higher than in the untreated groups. The effect of Ang II on SBP in groups that were treated with Est and L was lower than that in the DOCA-salt groups. Increase in SBP was strongly attenuated by Ang II in groups that were co-treated with both Est and L compared to the DOCA-treated rats. These results showed that Est significantly attenuated the effect of central Ang II on SBP in the DOCA-salt treated rats. Conclusion:: We suggest that there are interactions between E and Ang II in the control of blood pressure in DOCA-salt treated rats. Twit Text FOAVip Interaction of central Angiotensin II and estrogen on systolic blood pressure in female DOCA-salt treated rats ????Adv Biomed Res http://www.kidney.de/pget.php?&tw=1&pmid=27195251 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27195251 #FOAvip English Wikipedia <ref>{{Cite pmid|27195251}}</ref> Interaction of central Angiotensin II and estrogen on systolic blood pressure in female DOCA-salt treated rats #MMPMID27195251 Kafami M; Hosseini M; Niazmand S; Hadjzadeh MA; Farrokhi E; Mazloum T; Shafei MN Adv Biomed Res 2016[]; 5 (ä): ä PMID27195251show ga Background:: There is a probable interaction of central angiotensin II (Ang II) and estrogen (Est) on blood pressure in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Therefore, in the present study, the interaction between Ang II and Est in ovariectomized (Ovx) and Sham rats that were treated with DOCA- salt was evaluated. Materials and Methods:: The female rats were divided into 10 groups as follows: Sham, Ovx, Sham-DOCA, Ovx-DOCA, Sham-DOCA-estrogen (E), Ovx DOCA-E, Sham-DOCA-losartan (L), Ovx-DOCA-L, Sham?DOCA-L-E, and Ovx-DOCA-L-E. The Est groups received estradiol valerate (2 mg/kg; daily; subcutaneously (s.c)) for four weeks. Following that, several doses of Ang II (0.5, 5, 50, 500, 5000 ng/5 ?l) were injected via the intracerebroventricular (i.c.v) route and the changes in systolic blood pressure (SBP) were evaluated. In the losartan groups, 200 ?g losartan was injected (i.c.v) 15 minutes after the Ang II injection and the blood pressure was recorded. Treatment by DOCA was performed by removal of one kidney, injection of DOCA (45 mg/kg i.p), and adding of sodium chloride (NaCl) (1%) and potassium chloride (KCl) (0.1%) in the drinking water. Results:: The SBP was increased by Ang II and this effect in DOCA-salt treated rat was higher than in the untreated groups. The effect of Ang II on SBP in groups that were treated with Est and L was lower than that in the DOCA-salt groups. Increase in SBP was strongly attenuated by Ang II in groups that were co-treated with both Est and L compared to the DOCA-treated rats. These results showed that Est significantly attenuated the effect of central Ang II on SBP in the DOCA-salt treated rats. Conclusion:: We suggest that there are interactions between E and Ang II in the control of blood pressure in DOCA-salt treated rats. äInteraction of central Angiotensin II and estrogen on systolic blood p(epmc).pdf DeepDyve Pubget Overpricing