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10.1016/j.molmed.2014.10.007

http://scihub22266oqcxt.onion/10.1016/j.molmed.2014.10.007
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C4862830!4862830!25457619
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suck abstract from ncbi

pmid25457619      Trends+Mol+Med 2014 ; 20 (12): 685-93
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  • Clock genes, pancreatic function, and diabetes #MMPMID25457619
  • Vieira E; Burris TP; Quesada I
  • Trends Mol Med 2014[Dec]; 20 (12): 685-93 PMID25457619show ga
  • Circadian physiology is responsible for the temporal regulation of metabolism to optimize energy homeostasis throughout the day. Disturbances in the light/dark cycle, sleep/wake schedule, or feeding/activity behavior can affect the circadian function of the clocks located in the brain and peripheral tissues. These alterations have been associated with impaired glucose tolerance and type 2 diabetes. Animal models with molecular manipulation of clock genes and genetic studies in humans also support these links. It has been demonstrated that the endocrine pancreas has an intrinsic self-sustained clock, and recent studies have revealed an important role of clock genes in pancreatic ? cells, glucose homeostasis, and diabetes.
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