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10.7554/eLife.13552 http://scihub22266oqcxt.onion/10.7554/eLife.13552 C4862751!4862751!27077948     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       eLife 2016 ; 5 (ä): ä Nephropedia Template TP {{tp|p=27077948|t=2016. Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue |pdf=|usr=}}{{27077948}} gab.com Text Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=27077948 #FOAvip Metabolic homeostasis requires coordination between circadian clocks in different tissues. Also, systemic signals appear to be required for some transcriptional rhythms in the mammalian liver and the Drosophila fat body. Here we show that free-running oscillations of the fat body clock require clock function in the PDF-positive cells of the fly brain. Interestingly, rhythmic expression of the cytochrome P450 transcripts, sex-specific enzyme 1 (sxe1) and Cyp6a21, which cycle in the fat body independently of the local clock, depends upon clocks in neurons expressing neuropeptide F (NPF). NPF signaling itself is required to drive cycling of sxe1 and Cyp6a21 in the fat body, and its mammalian ortholog, Npy, functions similarly to regulate cycling of cytochrome P450 genes in the mouse liver. These data highlight the importance of neuronal clocks for peripheral rhythms, particularly in a specific detoxification pathway, and identify a novel and conserved role for NPF/Npy in circadian rhythms.DOI:http://dx.doi.org/10.7554/eLife.13552.001 Twit Text FOAVip Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=27077948 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27077948 #FOAvip English Wikipedia <ref>{{Cite pmid|27077948}}</ref> Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue #MMPMID27077948 Erion R; King AN; Wu G; Hogenesch JB; Sehgal A eLife 2016[]; 5 (ä): ä PMID27077948show ga Metabolic homeostasis requires coordination between circadian clocks in different tissues. Also, systemic signals appear to be required for some transcriptional rhythms in the mammalian liver and the Drosophila fat body. Here we show that free-running oscillations of the fat body clock require clock function in the PDF-positive cells of the fly brain. Interestingly, rhythmic expression of the cytochrome P450 transcripts, sex-specific enzyme 1 (sxe1) and Cyp6a21, which cycle in the fat body independently of the local clock, depends upon clocks in neurons expressing neuropeptide F (NPF). NPF signaling itself is required to drive cycling of sxe1 and Cyp6a21 in the fat body, and its mammalian ortholog, Npy, functions similarly to regulate cycling of cytochrome P450 genes in the mouse liver. These data highlight the importance of neuronal clocks for peripheral rhythms, particularly in a specific detoxification pathway, and identify a novel and conserved role for NPF/Npy in circadian rhythms.DOI:http://dx.doi.org/10.7554/eLife.13552.001 äNeural clocks and Neuropeptide F/Y regulate circadian gene expression (epmc).pdf DeepDyve Pubget Overpricing