Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/ni.3333 http://scihub22266oqcxt.onion/10.1038/ni.3333 C4862588!4862588 !26642356     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26642356 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26642356 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Immunol 2016 ; 17 (3 ): 250-8 Nephropedia Template TP {{tp|p=26642356 |t=2016. NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component |pdf=|usr=}}{{26642356 }} gab.com Text NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26642356 #FOAvip The NLRP3 inflammasome responds to microbes and danger signals by processing and activating proinflammatory cytokines, including interleukin 1? (IL-1?) and IL-18. We found here that activation of the NLRP3 inflammasome was restricted to interphase of the cell cycle by NEK7, a serine-threonine kinase previously linked to mitosis. Activation of the NLRP3 inflammasome required NEK7, which bound to the leucine-rich repeat domain of NLRP3 in a kinase-independent manner downstream of the induction of mitochondrial reactive oxygen species (ROS). This interaction was necessary for the formation of a complex containing NLRP3 and the adaptor ASC, oligomerization of ASC and activation of caspase-1. NEK7 promoted the NLRP3-dependent cellular inflammatory response to intraperitoneal challenge with monosodium urate and the development of experimental autoimmune encephalitis in mice. Our findings suggest that NEK7 serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division. Twit Text FOAVip NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26642356 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26642356 #FOAvip English Wikipedia <ref>{{Cite pmid|26642356 }}</ref> NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component #MMPMID26642356 Shi H ; Wang Y ; Li X ; Zhan X ; Tang M ; Fina M ; Su L ; Pratt D ; Bu CH ; Hildebrand S ; Lyon S ; Scott L ; Quan J ; Sun Q ; Russell J ; Arnett S ; Jurek P ; Chen D ; Kravchenko VV ; Mathison JC ; Moresco EM ; Monson NL ; Ulevitch RJ ; Beutler B Nat Immunol 2016[Mar]; 17 (3 ): 250-8 PMID26642356 show ga The NLRP3 inflammasome responds to microbes and danger signals by processing and activating proinflammatory cytokines, including interleukin 1? (IL-1?) and IL-18. We found here that activation of the NLRP3 inflammasome was restricted to interphase of the cell cycle by NEK7, a serine-threonine kinase previously linked to mitosis. Activation of the NLRP3 inflammasome required NEK7, which bound to the leucine-rich repeat domain of NLRP3 in a kinase-independent manner downstream of the induction of mitochondrial reactive oxygen species (ROS). This interaction was necessary for the formation of a complex containing NLRP3 and the adaptor ASC, oligomerization of ASC and activation of caspase-1. NEK7 promoted the NLRP3-dependent cellular inflammatory response to intraperitoneal challenge with monosodium urate and the development of experimental autoimmune encephalitis in mice. Our findings suggest that NEK7 serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division. |Animals [MESH] |Apoptosis [MESH] |Apoptosis Regulatory Proteins [MESH] |CARD Signaling Adaptor Proteins [MESH] |Carrier Proteins/genetics/*immunology [MESH] |Caspase 1 [MESH] |Chromatography, Gel [MESH] |Colony-Forming Units Assay [MESH] |Cytokines [MESH] |Cytoskeletal Proteins [MESH] |Dendritic Cells [MESH] |Encephalomyelitis, Autoimmune, Experimental/immunology [MESH] |Female [MESH] |Flow Cytometry [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Immunoprecipitation [MESH] |In Vitro Techniques [MESH] |Inflammasomes/genetics/immunology [MESH] |Macrophages, Peritoneal/immunology [MESH] |Macrophages/*immunology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Mitochondria/metabolism [MESH] |Mitosis/*immunology [MESH] |Monocytes [MESH] |NIMA-Related Kinases [MESH] |NLR Family, Pyrin Domain-Containing 3 Protein [MESH] |Protein Serine-Threonine Kinases/genetics/*immunology [MESH] |Reactive Oxygen Species [MESH]NLRP3 activation and mitosis are mutually exclusive events coordinated(epmc).pdf DeepDyve Pubget Overpricing