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10.2147/DDDT.S100095 http://scihub22266oqcxt.onion/10.2147/DDDT.S100095 C4862356!4862356!27217725     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Drug+Des+Devel+Ther 2016 ; 10 (ä): 1581-8 Nephropedia Template TP {{tp|p=27217725|t=2016. Spirolactone provides protection from renal fibrosis by inhibiting the endothelial?mesenchymal transition in isoprenaline-induced heart failure in rats |pdf=|usr=}}{{27217725}} gab.com Text Spirolactone provides protection from renal fibrosis by inhibiting the endothelial mesenchymal transition in isoprenaline-induced heart failure in rats JO: Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=27217725 #FOAvip Background: Fibrosis results in excessive accumulation of extracellular matrix proteins, collagen component alteration, and abnormalities in structure and is partly derived from a process called the endothelial?mesenchymal transition involving transforming growth factor ? (TGF-?). We investigated whether spironolactone, an aldosterone receptor blocker, attenuated isoprenaline (Iso)-induced heart failure in rats and also studied the mechanism for the same. Methods: Sprague?Dawley rats were subcutaneously injected with Iso to induce heart failure, which promoted renal fibrosis; rats with spironolactone treatment were given a gavage of spironolactone (30 or 60 mg/kg/d, for 21 days). Cardiac function and fibrosis indices were measured. Pathological alterations and expression of Type I and III collagen, ?-smooth muscle actin, cluster of differentiation-31, and TGF-? were examined. Results: In Iso-induced heart failure in rats, spironolactone significantly improved cardiac function and decreased myocardial fibrosis, reduced collagen fibrous proliferation in kidney, reduced expression of Type I and III collagen, increased the expression of cluster of differentiation-31, and decreased the expression of ?-smooth muscle actin and TGF-?. Conclusion: Spironolactone may prevent renal fibrosis by inhibiting the endothelial?mesenchymal transition. Twit Text FOAVip Spirolactone provides protection from renal fibrosis by inhibiting the endothelial mesenchymal transition in isoprenaline-induced heart failure in rats ????Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=27217725 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27217725 #FOAvip English Wikipedia <ref>{{Cite pmid|27217725}}</ref> Spirolactone provides protection from renal fibrosis by inhibiting the endothelial?mesenchymal transition in isoprenaline-induced heart failure in rats #MMPMID27217725 Zhou H; Xi D; Liu J; Zhao J; Chen S; Guo Z Drug Des Devel Ther 2016[]; 10 (ä): 1581-8 PMID27217725show ga Background: Fibrosis results in excessive accumulation of extracellular matrix proteins, collagen component alteration, and abnormalities in structure and is partly derived from a process called the endothelial?mesenchymal transition involving transforming growth factor ? (TGF-?). We investigated whether spironolactone, an aldosterone receptor blocker, attenuated isoprenaline (Iso)-induced heart failure in rats and also studied the mechanism for the same. Methods: Sprague?Dawley rats were subcutaneously injected with Iso to induce heart failure, which promoted renal fibrosis; rats with spironolactone treatment were given a gavage of spironolactone (30 or 60 mg/kg/d, for 21 days). Cardiac function and fibrosis indices were measured. Pathological alterations and expression of Type I and III collagen, ?-smooth muscle actin, cluster of differentiation-31, and TGF-? were examined. Results: In Iso-induced heart failure in rats, spironolactone significantly improved cardiac function and decreased myocardial fibrosis, reduced collagen fibrous proliferation in kidney, reduced expression of Type I and III collagen, increased the expression of cluster of differentiation-31, and decreased the expression of ?-smooth muscle actin and TGF-?. Conclusion: Spironolactone may prevent renal fibrosis by inhibiting the endothelial?mesenchymal transition. äSpirolactone provides protection from renal fibrosis by inhibiting the(epmc).pdf DeepDyve Pubget Overpricing