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10.1083/jcb.201603072 http://scihub22266oqcxt.onion/10.1083/jcb.201603072 C4862334!4862334 !27138255     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27138255 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Biol 2016 ; 213 (3 ): 343-54 Nephropedia Template TP {{tp|p=27138255 |t=2016. TANGO1 and Mia2/cTAGE5 (TALI) cooperate to export bulky pre-chylomicrons/VLDLs from the endoplasmic reticulum |pdf=|usr=}}{{27138255 }} gab.com Text TANGO1 and Mia2/cTAGE5 (TALI) cooperate to export bulky pre-chylomicrons/VLDLs from the endoplasmic reticulum JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27138255 #FOAvip Procollagens, pre-chylomicrons, and pre-very low-density lipoproteins (pre-VLDLs) are too big to fit into conventional COPII-coated vesicles, so how are these bulky cargoes exported from the endoplasmic reticulum (ER)? We have shown that TANGO1 located at the ER exit site is necessary for procollagen export. We report a role for TANGO1 and TANGO1-like (TALI), a chimeric protein resulting from fusion of MIA2 and cTAGE5 gene products, in the export of pre-chylomicrons and pre-VLDLs from the ER. TANGO1 binds TALI, and both interact with apolipoprotein B (ApoB) and are necessary for the recruitment of ApoB-containing lipid particles to ER exit sites for their subsequent export. Although export of ApoB requires the function of both TANGO1 and TALI, the export of procollagen XII by the same cells requires only TANGO1. These findings reveal a general role for TANGO1 in the export of bulky cargoes from the ER and identify a specific requirement for TALI in assisting TANGO1 to export bulky lipid particles. Twit Text FOAVip TANGO1 and Mia2/cTAGE5 (TALI) cooperate to export bulky pre-chylomicrons/VLDLs from the endoplasmic reticulum ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27138255 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27138255 #FOAvip English Wikipedia <ref>{{Cite pmid|27138255 }}</ref> TANGO1 and Mia2/cTAGE5 (TALI) cooperate to export bulky pre-chylomicrons/VLDLs from the endoplasmic reticulum #MMPMID27138255 Santos AJ ; Nogueira C ; Ortega-Bellido M ; Malhotra V J Cell Biol 2016[May]; 213 (3 ): 343-54 PMID27138255 show ga Procollagens, pre-chylomicrons, and pre-very low-density lipoproteins (pre-VLDLs) are too big to fit into conventional COPII-coated vesicles, so how are these bulky cargoes exported from the endoplasmic reticulum (ER)? We have shown that TANGO1 located at the ER exit site is necessary for procollagen export. We report a role for TANGO1 and TANGO1-like (TALI), a chimeric protein resulting from fusion of MIA2 and cTAGE5 gene products, in the export of pre-chylomicrons and pre-VLDLs from the ER. TANGO1 binds TALI, and both interact with apolipoprotein B (ApoB) and are necessary for the recruitment of ApoB-containing lipid particles to ER exit sites for their subsequent export. Although export of ApoB requires the function of both TANGO1 and TALI, the export of procollagen XII by the same cells requires only TANGO1. These findings reveal a general role for TANGO1 in the export of bulky cargoes from the ER and identify a specific requirement for TALI in assisting TANGO1 to export bulky lipid particles. |*Lipid Metabolism [MESH] |Antigens, Neoplasm/genetics/metabolism/*physiology [MESH] |Apolipoproteins B/metabolism [MESH] |Aryl Hydrocarbon Receptor Nuclear Translocator/genetics/metabolism/*physiology [MESH] |Autophagy [MESH] |Caco-2 Cells [MESH] |Collagen/metabolism [MESH] |Endoplasmic Reticulum/*metabolism [MESH] |Gene Deletion [MESH] |Hep G2 Cells [MESH] |Humans [MESH] |Lipoproteins, VLDL/metabolism [MESH] |Models, Biological [MESH] |Models, Molecular [MESH] |Mutant Chimeric Proteins/metabolism [MESH] |Neoplasm Proteins/genetics/metabolism/*physiology [MESH] |Protein Transport/physiology [MESH]TANGO1 and Mia2/cTAGE5 (TALI) cooperate to export bulky pre-chylomicro(epmc).pdf DeepDyve Pubget Overpricing