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10.1083/jcb.201510012 http://scihub22266oqcxt.onion/10.1083/jcb.201510012 C4862330!4862330 !27161398     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27161398 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Biol 2016 ; 213 (3 ): 371-83 Nephropedia Template TP {{tp|p=27161398 |t=2016. Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity |pdf=|usr=}}{{27161398 }} gab.com Text Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27161398 #FOAvip Integrin-dependent adhesions are mechanosensitive structures in which talin mediates a linkage to actin filaments either directly or indirectly by recruiting vinculin. Here, we report the development and validation of a talin tension sensor. We find that talin in focal adhesions is under tension, which is higher in peripheral than central adhesions. Tension on talin is increased by vinculin and depends mainly on actin-binding site 2 (ABS2) within the middle of the rod domain, rather than ABS3 at the far C terminus. Unlike vinculin, talin is under lower tension on soft substrates. The difference between central and peripheral adhesions requires ABS3 but not vinculin or ABS2. However, differential stiffness sensing by talin requires ABS2 but not vinculin or ABS3. These results indicate that central versus peripheral adhesions must be organized and regulated differently, and that ABS2 and ABS3 have distinct functions in spatial variations and stiffness sensing. Overall, these results shed new light on talin function and constrain models for cellular mechanosensing. Twit Text FOAVip Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27161398 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27161398 #FOAvip English Wikipedia <ref>{{Cite pmid|27161398 }}</ref> Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity #MMPMID27161398 Kumar A ; Ouyang M ; Van den Dries K ; McGhee EJ ; Tanaka K ; Anderson MD ; Groisman A ; Goult BT ; Anderson KI ; Schwartz MA J Cell Biol 2016[May]; 213 (3 ): 371-83 PMID27161398 show ga Integrin-dependent adhesions are mechanosensitive structures in which talin mediates a linkage to actin filaments either directly or indirectly by recruiting vinculin. Here, we report the development and validation of a talin tension sensor. We find that talin in focal adhesions is under tension, which is higher in peripheral than central adhesions. Tension on talin is increased by vinculin and depends mainly on actin-binding site 2 (ABS2) within the middle of the rod domain, rather than ABS3 at the far C terminus. Unlike vinculin, talin is under lower tension on soft substrates. The difference between central and peripheral adhesions requires ABS3 but not vinculin or ABS2. However, differential stiffness sensing by talin requires ABS2 but not vinculin or ABS3. These results indicate that central versus peripheral adhesions must be organized and regulated differently, and that ABS2 and ABS3 have distinct functions in spatial variations and stiffness sensing. Overall, these results shed new light on talin function and constrain models for cellular mechanosensing. |*Mechanotransduction, Cellular [MESH] |Actin Cytoskeleton/metabolism [MESH] |Animals [MESH] |Binding Sites [MESH] |Fluorescence Resonance Energy Transfer [MESH] |Focal Adhesions [MESH] |Mice [MESH] |Models, Biological [MESH] |NIH 3T3 Cells [MESH] |Talin/metabolism/*physiology [MESH]Talin tension sensor reveals novel features of focal adhesion force tr(epmc).pdf DeepDyve Pubget Overpricing