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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Genome+Biol 2016 ; 17 (ä): ä Nephropedia Template TP
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Transposable elements in the mammalian embryo: pioneers surviving through stealth and service #MMPMID27161170
Gerdes P; Richardson SR; Mager DL; Faulkner GJ
Genome Biol 2016[]; 17 (ä): ä PMID27161170show ga
Transposable elements (TEs) are notable drivers of genetic innovation. Over evolutionary time, TE insertions can supply new promoter, enhancer, and insulator elements to protein-coding genes and establish novel, species-specific gene regulatory networks. Conversely, ongoing TE-driven insertional mutagenesis, nonhomologous recombination, and other potentially deleterious processes can cause sporadic disease by disrupting genome integrity or inducing abrupt gene expression changes. Here, we discuss recent evidence suggesting that TEs may contribute regulatory innovation to mammalian embryonic and pluripotent states as a means to ward off complete repression by their host genome.