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10.1186/s13063-016-1367-4 http://scihub22266oqcxt.onion/10.1186/s13063-016-1367-4 C4862046!4862046!27165260     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trials 2016 ; 17 (ä): ä Nephropedia Template TP {{tp|p=27165260|t=2016. Stopping guidelines for an effectiveness trial: what should the protocol specify?|pdf=|usr=}}{{27165260}} gab.com Text Stopping guidelines for an effectiveness trial: what should the protocol specify JO: Trials http://www.kidney.de/pget.php?&tw=1&pmid=27165260 #FOAvip Background: Despite long-standing problems in decisions to stop clinical trials, stopping guidelines are often vague or unspecified in the trial protocol. Clear, well-conceived guidelines are especially important to assist the data monitoring committees for effectiveness trials. Main text: To specify better stopping guidelines in the protocol for such trials, the clinical investigators and trial statistician should carefully consider the following kinds of questions:How should the relative importance of the treatment benefits and hazards be assessed?For decisions to stop a trial for benefit:What would be the minimum clinically important difference for the study population?How should the probability that the benefit exceeds that difference be assessed?When should the interim analyses include data from other trials?Would the evidence meet state-of-the-art standards for treatment recommendations and practice guidelines?Should less evidence be required to stop the trial for harm than for benefit?When should conventional stopping guidelines for futility be used for comparative effectiveness trials? Conclusion: Both clinical and statistical expertise are required to address such challenging questions for effectiveness trials. Their joint consideration by clinical investigators and statisticians is needed to define better stopping guidelines before starting the trial. Twit Text FOAVip Stopping guidelines for an effectiveness trial: what should the protocol specify ????Trials http://www.kidney.de/pget.php?&tw=1&pmid=27165260 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27165260 #FOAvip English Wikipedia <ref>{{Cite pmid|27165260}}</ref> Stopping guidelines for an effectiveness trial: what should the protocol specify? #MMPMID27165260 Tyson JE; Pedroza C; Wallace D; D?Angio C; Bell EF; Das A Trials 2016[]; 17 (ä): ä PMID27165260show ga Background: Despite long-standing problems in decisions to stop clinical trials, stopping guidelines are often vague or unspecified in the trial protocol. Clear, well-conceived guidelines are especially important to assist the data monitoring committees for effectiveness trials. Main text: To specify better stopping guidelines in the protocol for such trials, the clinical investigators and trial statistician should carefully consider the following kinds of questions:How should the relative importance of the treatment benefits and hazards be assessed?For decisions to stop a trial for benefit:What would be the minimum clinically important difference for the study population?How should the probability that the benefit exceeds that difference be assessed?When should the interim analyses include data from other trials?Would the evidence meet state-of-the-art standards for treatment recommendations and practice guidelines?Should less evidence be required to stop the trial for harm than for benefit?When should conventional stopping guidelines for futility be used for comparative effectiveness trials? Conclusion: Both clinical and statistical expertise are required to address such challenging questions for effectiveness trials. Their joint consideration by clinical investigators and statisticians is needed to define better stopping guidelines before starting the trial. äStopping guidelines for an effectiveness trial: what should the protoc(epmc).pdf DeepDyve Pubget Overpricing