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10.1016/j.ymeth.2014.11.008 http://scihub22266oqcxt.onion/10.1016/j.ymeth.2014.11.008 C4861994!4861994!25462559     free     free     free       Methods 2015 ; 77-78 (ä): 164-71 Nephropedia Template TP {{tp|p=25462559|t=2015. Analysis of intracellular PTEN signaling and secretion |pdf=|usr=}}{{25462559}} gab.com Text Analysis of intracellular PTEN signaling and secretion JO: Methods http://www.kidney.de/pget.php?&tw=1&pmid=25462559 #FOAvip The tumor suppressor PTEN dephosphorylates PIP3 to inhibit PI3K signaling in cells. Altering PTEN intracellular signaling can therefore significantly affect cell behavior. Two novel mechanisms of PTEN regulation including the secretion and entry of the translational variant PTEN-L, and enzymatic inhibition by the interacting protein P-REX2, have been shown to modulate PI3K signaling, cellular proliferation and survival, and glucose metabolism. Here, we review the methods used to identify and validate the existence of both PTEN-L and the P-REX2?PTEN complex, to determine their effects on PTEN phosphatase activity, and to examine their role in cellular physiology. Twit Text FOAVip Analysis of intracellular PTEN signaling and secretion ????Methods http://www.kidney.de/pget.php?&tw=1&pmid=25462559 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25462559 #FOAvip English Wikipedia <ref>{{Cite pmid|25462559}}</ref> Analysis of intracellular PTEN signaling and secretion #MMPMID25462559 Hodakoski C; Fine B; Hopkins B; Parsons R Methods 2015[May]; 77-78 (ä): 164-71 PMID25462559show ga The tumor suppressor PTEN dephosphorylates PIP3 to inhibit PI3K signaling in cells. Altering PTEN intracellular signaling can therefore significantly affect cell behavior. Two novel mechanisms of PTEN regulation including the secretion and entry of the translational variant PTEN-L, and enzymatic inhibition by the interacting protein P-REX2, have been shown to modulate PI3K signaling, cellular proliferation and survival, and glucose metabolism. Here, we review the methods used to identify and validate the existence of both PTEN-L and the P-REX2?PTEN complex, to determine their effects on PTEN phosphatase activity, and to examine their role in cellular physiology. äAnalysis of intracellular PTEN signaling and secretion (epmc).pdf DeepDyve Pubget Overpricing