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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Scientifica+(Cairo) 2016 ; 2016 (ä): ä Nephropedia Template TP
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Gentamicin Induced Nephrotoxicity: The Role of Sex Hormones in Gonadectomized Male and Female Rats #MMPMID27213082
Scientifica (Cairo) 2016[]; 2016 (ä): ä PMID27213082show ga
Background. Gentamicin (GM) induced nephrotoxicity may be sex hormones related. The effects of sex hormones on GM induced nephrotoxicity in gonadectomized rats were investigated. Methods. Ovariectomized rats received 0.25, 0.5, or 1?mg/kg/week of estradiol (ES) alone or accompanied with 10?mg/kg/week of progesterone (Pro) for two weeks followed by GM (100?mg/kg/day) for 9 days. Castrated rats were also treated with 10, 50, or 100?mg/kg/week of testosterone (TS) for two weeks and then received GM. In addition, a single castrated group received 0.25?mg/kg/week of ES plus GM. Results. GM increased the serum levels of blood urea nitrogen (BUN) and creatinine (Cr) and kidney tissue damage score (KTDS) (P < 0.05). TS had no effect on the serum levels of BUN and Cr and KTDS, while low dose of ES intensified these parameters in male (P < 0.05). ES (0.5?mg/kg) without Pro ameliorated KTDS in female (P < 0.05) while ES (1?mg/kg) with or without Pro exacerbated the BUN values and Cr values, KTDS, and body weight loss (P < 0.05). Conclusion. ES (0.5?mg/kg) without Pro ameliorated kidney damage induced by GM in female while neither TS nor ES had beneficial effect on nephrotoxicity induced by GM in male, although ES aggravated it.