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10.1016/j.ajpath.2015.12.015 http://scihub22266oqcxt.onion/10.1016/j.ajpath.2015.12.015 C4861757!4861757!26948422     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Pathol 2016 ; 186 (5): 1166-79 Nephropedia Template TP {{tp|p=26948422|t=2016. Induction of Colonic M Cells during Intestinal Inflammation |pdf=|usr=}}{{26948422}} gab.com Text Induction of Colonic M Cells during Intestinal Inflammation JO: Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26948422 #FOAvip Intestinal M (microfold) cells are specialized epithelial cells overlying lymphoid tissues in the small intestine. Unlike common enterocytes, M cells lack an organized apical brush border, and are able to transcytose microparticles across the mucosal barrier to underlying antigen-presenting cells. We found that in both the dextran sodium sulfate and Citrobacter rodentium models of colitis, significantly increased numbers of Peyer's patch (PP) phenotype M cells were induced at the peak of inflammation in colonic epithelium, often accompanied by loosely organized lamina propria infiltrates. PP type M cells are thought to be dependent on cytokines, including tumor necrosis factor (TNF)-? and receptor activator of nuclear factor kappa-B ligand; these cytokines were also found to be induced in the inflamed tissues. The induction of M cells was abrogated by anti?TNF-? blockade, suggesting that anti?TNF-? therapies may have similar effects in clinical settings, although the functional consequences are not clear. Our results suggest that inflammatory cytokine-induced PP type M cells may be a useful correlate of chronic intestinal inflammation. Twit Text FOAVip Induction of Colonic M Cells during Intestinal Inflammation ????Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26948422 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26948422 #FOAvip English Wikipedia <ref>{{Cite pmid|26948422}}</ref> Induction of Colonic M Cells during Intestinal Inflammation #MMPMID26948422 Bennett KM; Parnell EA; Sanscartier C; Parks S; Chen G; Nair MG; Lo DD Am J Pathol 2016[May]; 186 (5): 1166-79 PMID26948422show ga Intestinal M (microfold) cells are specialized epithelial cells overlying lymphoid tissues in the small intestine. Unlike common enterocytes, M cells lack an organized apical brush border, and are able to transcytose microparticles across the mucosal barrier to underlying antigen-presenting cells. We found that in both the dextran sodium sulfate and Citrobacter rodentium models of colitis, significantly increased numbers of Peyer's patch (PP) phenotype M cells were induced at the peak of inflammation in colonic epithelium, often accompanied by loosely organized lamina propria infiltrates. PP type M cells are thought to be dependent on cytokines, including tumor necrosis factor (TNF)-? and receptor activator of nuclear factor kappa-B ligand; these cytokines were also found to be induced in the inflamed tissues. The induction of M cells was abrogated by anti?TNF-? blockade, suggesting that anti?TNF-? therapies may have similar effects in clinical settings, although the functional consequences are not clear. Our results suggest that inflammatory cytokine-induced PP type M cells may be a useful correlate of chronic intestinal inflammation. äInduction of Colonic M Cells during Intestinal Inflammation (epmc).pdf DeepDyve Pubget Overpricing