Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26993507
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Matrix Metalloproteinase-Mediated Neuroinflammation in Vascular Cognitive
Impairment of the Binswanger Type
#MMPMID26993507
Rosenberg GA
Cell Mol Neurobiol
2016[Mar]; 36
(2
): 195-202
PMID26993507
show ga
Vascular cognitive impairment (VCI) is a heterogeneous group of diseases linked
together by cerebrovascular disease. Treatment of VCI has been hindered by the
lack of a coherent pathophysiological process that could provide molecular
targets. Of the several forms of VCI, the small vessel disease form is both the
most prevalent and generally has a progressive course. Binswanger's disease (BD)
is the small vessel form of VCI that involves extensive injury to the deep white
matter. Growing evidence suggests that there is disruption of the blood-brain
barrier (BBB) secondary to an inflammatory state. Matrix metalloproteinases
(MMPs) are increased in the brain and CSF of patients with BD, and have been
shown to disrupt the BBB in animal studies, suggesting that they may be
biomarkers and therapeutic targets. Multimodal biomarkers derived from clinical,
neuropsychological, imaging, and biochemical data can be used to narrow the VCI
population to the progressive inflammatory form that will be optimal for
treatment trials. This review describes the role of the MMPs in pathophysiology
and their use as biomarkers.
free
free
free
