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10.1074/jbc.M115.704239 http://scihub22266oqcxt.onion/10.1074/jbc.M115.704239 C4861476!4861476!26841869     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2016 ; 291 (17): 9073-86 Nephropedia Template TP {{tp|p=26841869|t=2016. Ikaros Is a Negative Regulator of B1 Cell Development and Function* |pdf=|usr=}}{{26841869}} gab.com Text Ikaros Is a Negative Regulator of B1 Cell Development and Function* JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26841869 #FOAvip B1 B cells secrete most of the circulating natural antibodies and are considered key effector cells of the innate immune response. However, B1 cell-associated antibodies often cross-react with self-antigens, which leads to autoimmunity, and B1 cells have been implicated in cancer. How B1 cell activity is regulated remains unclear. We show that the Ikaros transcription factor is a major negative regulator of B1 cell development and function. Using conditional knock-out mouse models to delete Ikaros at different locations, we show that Ikaros-deficient mice exhibit specific and significant increases in splenic and bone marrow B1 cell numbers, and that the B1 progenitor cell pool is increased ?10-fold in the bone marrow. Ikaros-null B1 cells resemble WT B1 cells at the molecular and cellular levels, but show a down-regulation of signaling components important for inhibiting proliferation and immunoglobulin production. Ikaros-null B1 cells hyper-react to TLR4 stimulation and secrete high amounts of IgM autoantibodies. These results indicate that Ikaros is required to limit B1 cell homeostasis in the adult. Twit Text FOAVip Ikaros Is a Negative Regulator of B1 Cell Development and Function* ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26841869 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26841869 #FOAvip English Wikipedia <ref>{{Cite pmid|26841869}}</ref> Ikaros Is a Negative Regulator of B1 Cell Development and Function* #MMPMID26841869 Macias-Garcia A; Heizmann B; Sellars M; Marchal P; Dali H; Pasquali JL; Muller S; Kastner P; Chan S J Biol Chem 2016[Apr]; 291 (17): 9073-86 PMID26841869show ga B1 B cells secrete most of the circulating natural antibodies and are considered key effector cells of the innate immune response. However, B1 cell-associated antibodies often cross-react with self-antigens, which leads to autoimmunity, and B1 cells have been implicated in cancer. How B1 cell activity is regulated remains unclear. We show that the Ikaros transcription factor is a major negative regulator of B1 cell development and function. Using conditional knock-out mouse models to delete Ikaros at different locations, we show that Ikaros-deficient mice exhibit specific and significant increases in splenic and bone marrow B1 cell numbers, and that the B1 progenitor cell pool is increased ?10-fold in the bone marrow. Ikaros-null B1 cells resemble WT B1 cells at the molecular and cellular levels, but show a down-regulation of signaling components important for inhibiting proliferation and immunoglobulin production. Ikaros-null B1 cells hyper-react to TLR4 stimulation and secrete high amounts of IgM autoantibodies. These results indicate that Ikaros is required to limit B1 cell homeostasis in the adult. äIkaros Is a Negative Regulator of B1 Cell Development and Function* (epmc).pdf DeepDyve Pubget Overpricing