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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Biol+Chem 2016 ; 291 (17): 8969-77 Nephropedia Template TP
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The ?-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors* #MMPMID26984408
Smith JS; Rajagopal S
J Biol Chem 2016[Apr]; 291 (17): 8969-77 PMID26984408show ga
The ?-arrestins (?arrs) are versatile, multifunctional adapter proteins that are best known for their ability to desensitize G protein-coupled receptors (GPCRs), but also regulate a diverse array of cellular functions. To signal in such a complex fashion, ?arrs adopt multiple conformations and are regulated at multiple levels to differentially activate downstream pathways. Recent structural studies have demonstrated that ?arrs have a conserved structure and activation mechanism, with plasticity of their structural fold, allowing them to adopt a wide array of conformations. Novel roles for ?arrs continue to be identified, demonstrating the importance of these dynamic regulators of cellular signaling.