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10.1074/jbc.R115.713313

http://scihub22266oqcxt.onion/10.1074/jbc.R115.713313
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C4861465!4861465!26984408
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suck abstract from ncbi


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pmid26984408      J+Biol+Chem 2016 ; 291 (17): 8969-77
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  • The ?-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors* #MMPMID26984408
  • Smith JS; Rajagopal S
  • J Biol Chem 2016[Apr]; 291 (17): 8969-77 PMID26984408show ga
  • The ?-arrestins (?arrs) are versatile, multifunctional adapter proteins that are best known for their ability to desensitize G protein-coupled receptors (GPCRs), but also regulate a diverse array of cellular functions. To signal in such a complex fashion, ?arrs adopt multiple conformations and are regulated at multiple levels to differentially activate downstream pathways. Recent structural studies have demonstrated that ?arrs have a conserved structure and activation mechanism, with plasticity of their structural fold, allowing them to adopt a wide array of conformations. Novel roles for ?arrs continue to be identified, demonstrating the importance of these dynamic regulators of cellular signaling.
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