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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Biol+Chem
2016 ; 291
(16
): 8825-35
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Molecular Circuitry of the SUMO (Small Ubiquitin-like Modifier) Pathway in
Controlling Sumoylation Homeostasis and Suppressing Genome Rearrangements
#MMPMID26921322
de Albuquerque CP
; Liang J
; Gaut NJ
; Zhou H
J Biol Chem
2016[Apr]; 291
(16
): 8825-35
PMID26921322
show ga
Small ubiquitin-like modifier (SUMO) E3 ligases are known to have a major role in
preventing gross chromosomal rearrangements (GCRs); however, relatively little is
known about the role of SUMO isopeptidases in genome maintenance and their role
in controlling intracellular sumoylation homeostasis. Here we show the SUMO
isopeptidase Ulp2 in Saccharomyces cerevisiae does not prevent the accumulation
of GCRs, and interestingly, its loss causes subunit-specific changes of
sumoylated minichromosome maintenance (MCM) helicase in addition to drastic
accumulation of sumoylated nucleolar RENT and inner kinetochore complexes. In
contrast, loss of Ulp1 or its mis-localization from the nuclear periphery causes
substantial accumulations of GCRs and elevated sumoylation of most proteins
except for Ulp2 targets. Interestingly, the E3 ligase Mms21, which has a major
role in genome maintenance, preferentially controls the sumoylation of Mcm3
during DNA replication. These findings reveal distinct roles for Ulp1 and Ulp2 in
controlling homeostasis of intracellular sumoylation and show that sumoylation of
MCM is controlled in a subunit-specific and cell cycle dependent manner.
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