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10.1074/jbc.M115.691774 http://scihub22266oqcxt.onion/10.1074/jbc.M115.691774 C4861439!4861439!26893374     free     free     free       J+Biol+Chem 2016 ; 291 (16): 8701-8 Nephropedia Template TP {{tp|p=26893374|t=2016. Intracellular pH Modulates Autophagy and Mitophagy* |pdf=|usr=}}{{26893374}} gab.com Text Intracellular pH Modulates Autophagy and Mitophagy* JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26893374 #FOAvip The specific autophagic elimination of mitochondria (mitophagy) plays the role of quality control for this organelle. Deregulation of mitophagy leads to an increased number of damaged mitochondria and triggers cell death. The deterioration of mitophagy has been hypothesized to underlie the pathogenesis of several neurodegenerative diseases, most notably Parkinson disease. Although some of the biochemical and molecular mechanisms of mitochondrial quality control are described in detail, physiological or pathological triggers of mitophagy are still not fully characterized. Here we show that the induction of mitophagy by the mitochondrial uncoupler FCCP is independent of the effect of mitochondrial membrane potential but dependent on acidification of the cytosol by FCCP. The ionophore nigericin also reduces cytosolic pH and induces PINK1/PARKIN-dependent and -independent mitophagy. The increase of intracellular pH with monensin suppresses the effects of FCCP and nigericin on mitochondrial degradation. Thus, a change in intracellular pH is a regulator of mitochondrial quality control. Twit Text FOAVip Intracellular pH Modulates Autophagy and Mitophagy* ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26893374 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26893374 #FOAvip English Wikipedia <ref>{{Cite pmid|26893374}}</ref> Intracellular pH Modulates Autophagy and Mitophagy* #MMPMID26893374 Berezhnov AV; Soutar MPM; Fedotova EI; Frolova MS; Plun-Favreau H; Zinchenko VP; Abramov AY J Biol Chem 2016[Apr]; 291 (16): 8701-8 PMID26893374show ga The specific autophagic elimination of mitochondria (mitophagy) plays the role of quality control for this organelle. Deregulation of mitophagy leads to an increased number of damaged mitochondria and triggers cell death. The deterioration of mitophagy has been hypothesized to underlie the pathogenesis of several neurodegenerative diseases, most notably Parkinson disease. Although some of the biochemical and molecular mechanisms of mitochondrial quality control are described in detail, physiological or pathological triggers of mitophagy are still not fully characterized. Here we show that the induction of mitophagy by the mitochondrial uncoupler FCCP is independent of the effect of mitochondrial membrane potential but dependent on acidification of the cytosol by FCCP. The ionophore nigericin also reduces cytosolic pH and induces PINK1/PARKIN-dependent and -independent mitophagy. The increase of intracellular pH with monensin suppresses the effects of FCCP and nigericin on mitochondrial degradation. Thus, a change in intracellular pH is a regulator of mitochondrial quality control. äIntracellular pH Modulates Autophagy and Mitophagy* (epmc).pdf DeepDyve Pubget Overpricing