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10.1074/jbc.M115.713008 http://scihub22266oqcxt.onion/10.1074/jbc.M115.713008 C4861418!4861418 !26826124     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26826124 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2016 ; 291 (16 ): 8440-52 Nephropedia Template TP {{tp|p=26826124 |t=2016. T Cell Receptor-induced Nuclear Factor ?B (NF-?B) Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1-mediated Calcium Entry |pdf=|usr=}}{{26826124 }} gab.com Text T Cell Receptor-induced Nuclear Factor B (NF- B) Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1-mediated Calcium Entry JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26826124 #FOAvip T cell activation following antigen binding to the T cell receptor (TCR) involves the mobilization of intracellular Ca(2+) to activate the key transcription factors nuclear factor of activated T lymphocytes (NFAT) and NF-?B. The mechanism of NFAT activation by Ca(2+) has been determined. However, the role of Ca(2+) in controlling NF-?B signaling is poorly understood, and the source of Ca(2+) required for NF-?B activation is unknown. We demonstrate that TCR- but not TNF-induced NF-?B signaling upstream of I?B kinase activation absolutely requires the influx of extracellular Ca(2+) via STIM1-dependent Ca(2+) release-activated Ca(2+)/Orai channels. We further show that Ca(2+) influx controls phosphorylation of the NF-?B protein p65 on Ser-536 and that this posttranslational modification controls its nuclear localization and transcriptional activation. Notably, our data reveal that this role for Ca(2+) is entirely separate from its upstream control of I?B? degradation, thereby identifying a novel Ca(2+)-dependent distal step in TCR-induced NF-?B activation. Finally, we demonstrate that this control of distal signaling occurs via Ca(2+)-dependent PKC?-mediated phosphorylation of p65. Thus, we establish the source of Ca(2+) required for TCR-induced NF-?B activation and define a new distal Ca(2+)-dependent checkpoint in TCR-induced NF-?B signaling that has broad implications for the control of immune cell development and T cell functional specificity. Twit Text FOAVip T Cell Receptor-induced Nuclear Factor B (NF- B) Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1-mediated Calcium Entry ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26826124 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26826124 #FOAvip English Wikipedia <ref>{{Cite pmid|26826124 }}</ref> T Cell Receptor-induced Nuclear Factor ?B (NF-?B) Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1-mediated Calcium Entry #MMPMID26826124 Liu X ; Berry CT ; Ruthel G ; Madara JJ ; MacGillivray K ; Gray CM ; Madge LA ; McCorkell KA ; Beiting DP ; Hershberg U ; May MJ ; Freedman BD J Biol Chem 2016[Apr]; 291 (16 ): 8440-52 PMID26826124 show ga T cell activation following antigen binding to the T cell receptor (TCR) involves the mobilization of intracellular Ca(2+) to activate the key transcription factors nuclear factor of activated T lymphocytes (NFAT) and NF-?B. The mechanism of NFAT activation by Ca(2+) has been determined. However, the role of Ca(2+) in controlling NF-?B signaling is poorly understood, and the source of Ca(2+) required for NF-?B activation is unknown. We demonstrate that TCR- but not TNF-induced NF-?B signaling upstream of I?B kinase activation absolutely requires the influx of extracellular Ca(2+) via STIM1-dependent Ca(2+) release-activated Ca(2+)/Orai channels. We further show that Ca(2+) influx controls phosphorylation of the NF-?B protein p65 on Ser-536 and that this posttranslational modification controls its nuclear localization and transcriptional activation. Notably, our data reveal that this role for Ca(2+) is entirely separate from its upstream control of I?B? degradation, thereby identifying a novel Ca(2+)-dependent distal step in TCR-induced NF-?B activation. Finally, we demonstrate that this control of distal signaling occurs via Ca(2+)-dependent PKC?-mediated phosphorylation of p65. Thus, we establish the source of Ca(2+) required for TCR-induced NF-?B activation and define a new distal Ca(2+)-dependent checkpoint in TCR-induced NF-?B signaling that has broad implications for the control of immune cell development and T cell functional specificity. |Calcium Channels/*biosynthesis/genetics [MESH] |Calcium Signaling/*physiology [MESH] |Calcium/*metabolism [MESH] |Humans [MESH] |Jurkat Cells [MESH] |Membrane Proteins/*biosynthesis/genetics [MESH] |Neoplasm Proteins/*biosynthesis/genetics [MESH] |ORAI1 Protein [MESH] |Phosphorylation/physiology [MESH] |Receptors, Antigen, T-Cell/genetics/*metabolism [MESH] |Stromal Interaction Molecule 1 [MESH] |T-Lymphocytes/*metabolism [MESH] |Transcription Factor RelA/genetics/*metabolism [MESH]T Cell Receptor-induced Nuclear Factor ?B (NF-?B) Signaling and Transc(epmc).pdf DeepDyve Pubget Overpricing