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10.1074/jbc.M115.713008 http://scihub22266oqcxt.onion/10.1074/jbc.M115.713008 C4861418!4861418!26826124     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26826124.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2016 ; 291 (16): 8440-52 Nephropedia Template TP {{tp|p=26826124|t=2016. T Cell Receptor-induced Nuclear Factor ?B (NF-?B) Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1-mediated Calcium Entry* |pdf=|usr=}}{{26826124}} gab.com Text T Cell Receptor-induced Nuclear Factor B (NF- B) Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1-mediated Calcium Entry* JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26826124 #FOAvip T cell activation following antigen binding to the T cell receptor (TCR) involves the mobilization of intracellular Ca2+ to activate the key transcription factors nuclear factor of activated T lymphocytes (NFAT) and NF-?B. The mechanism of NFAT activation by Ca2+ has been determined. However, the role of Ca2+ in controlling NF-?B signaling is poorly understood, and the source of Ca2+ required for NF-?B activation is unknown. We demonstrate that TCR- but not TNF-induced NF-?B signaling upstream of I?B kinase activation absolutely requires the influx of extracellular Ca2+ via STIM1-dependent Ca2+ release-activated Ca2+/Orai channels. We further show that Ca2+ influx controls phosphorylation of the NF-?B protein p65 on Ser-536 and that this posttranslational modification controls its nuclear localization and transcriptional activation. Notably, our data reveal that this role for Ca2+ is entirely separate from its upstream control of I?B? degradation, thereby identifying a novel Ca2+-dependent distal step in TCR-induced NF-?B activation. Finally, we demonstrate that this control of distal signaling occurs via Ca2+-dependent PKC?-mediated phosphorylation of p65. Thus, we establish the source of Ca2+ required for TCR-induced NF-?B activation and define a new distal Ca2+-dependent checkpoint in TCR-induced NF-?B signaling that has broad implications for the control of immune cell development and T cell functional specificity. Twit Text FOAVip T Cell Receptor-induced Nuclear Factor B (NF- B) Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1-mediated Calcium Entry* ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26826124 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26826124 #FOAvip English Wikipedia <ref>{{Cite pmid|26826124}}</ref> T Cell Receptor-induced Nuclear Factor ?B (NF-?B) Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1-mediated Calcium Entry* #MMPMID26826124 Liu X; Berry CT; Ruthel G; Madara JJ; MacGillivray K; Gray CM; Madge LA; McCorkell KA; Beiting DP; Hershberg U; May MJ; Freedman BD J Biol Chem 2016[Apr]; 291 (16): 8440-52 PMID26826124show ga T cell activation following antigen binding to the T cell receptor (TCR) involves the mobilization of intracellular Ca2+ to activate the key transcription factors nuclear factor of activated T lymphocytes (NFAT) and NF-?B. The mechanism of NFAT activation by Ca2+ has been determined. However, the role of Ca2+ in controlling NF-?B signaling is poorly understood, and the source of Ca2+ required for NF-?B activation is unknown. We demonstrate that TCR- but not TNF-induced NF-?B signaling upstream of I?B kinase activation absolutely requires the influx of extracellular Ca2+ via STIM1-dependent Ca2+ release-activated Ca2+/Orai channels. We further show that Ca2+ influx controls phosphorylation of the NF-?B protein p65 on Ser-536 and that this posttranslational modification controls its nuclear localization and transcriptional activation. Notably, our data reveal that this role for Ca2+ is entirely separate from its upstream control of I?B? degradation, thereby identifying a novel Ca2+-dependent distal step in TCR-induced NF-?B activation. Finally, we demonstrate that this control of distal signaling occurs via Ca2+-dependent PKC?-mediated phosphorylation of p65. Thus, we establish the source of Ca2+ required for TCR-induced NF-?B activation and define a new distal Ca2+-dependent checkpoint in TCR-induced NF-?B signaling that has broad implications for the control of immune cell development and T cell functional specificity. äT Cell Receptor-induced Nuclear Factor ?B (NF-?B) Signaling and Transc(epmc).pdf DeepDyve Pubget Overpricing