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10.1371/journal.pone.0154630 http://scihub22266oqcxt.onion/10.1371/journal.pone.0154630 C4861286!4861286!27159398     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2016 ; 11 (5): ä Nephropedia Template TP {{tp|p=27159398|t=2016. Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis |pdf=|usr=}}{{27159398}} gab.com Text Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27159398 #FOAvip Here, we investigate induction of immunological tolerance by lentiviral based gene therapy in a mouse model of rheumatoid arthritis, collagen II-induced arthritis (CIA). Targeting the expression of the collagen type II (CII) to antigen presenting cells (APCs) induced antigen-specific tolerance, where only 5% of the mice developed arthritis as compared with 95% of the control mice. In the CII-tolerized mice, the proportion of Tregs as well as mRNA expression of SOCS1 (suppressors of cytokine signaling 1) increased at day 3 after CII immunization. Transfer of B cells or non-B cell APC, as well as T cells, from tolerized to naïve mice all mediated a certain degree of tolerance. Thus, sustainable tolerance is established very early during the course of arthritis and is mediated by both B and non-B cells as APCs. This novel approach for inducing tolerance to disease specific antigens can be used for studying tolerance mechanisms, not only in CIA but also in other autoimmune diseases. Twit Text FOAVip Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27159398 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27159398 #FOAvip English Wikipedia <ref>{{Cite pmid|27159398}}</ref> Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis #MMPMID27159398 Tengvall S; Eneljung T; Jirholt P; Turesson O; Wing K; Holmdahl R; Kihlberg J; Stern A; Mårtensson IL; Henningsson L; Gustafsson K; Gjertsson I PLoS One 2016[]; 11 (5): ä PMID27159398show ga Here, we investigate induction of immunological tolerance by lentiviral based gene therapy in a mouse model of rheumatoid arthritis, collagen II-induced arthritis (CIA). Targeting the expression of the collagen type II (CII) to antigen presenting cells (APCs) induced antigen-specific tolerance, where only 5% of the mice developed arthritis as compared with 95% of the control mice. In the CII-tolerized mice, the proportion of Tregs as well as mRNA expression of SOCS1 (suppressors of cytokine signaling 1) increased at day 3 after CII immunization. Transfer of B cells or non-B cell APC, as well as T cells, from tolerized to naïve mice all mediated a certain degree of tolerance. Thus, sustainable tolerance is established very early during the course of arthritis and is mediated by both B and non-B cells as APCs. This novel approach for inducing tolerance to disease specific antigens can be used for studying tolerance mechanisms, not only in CIA but also in other autoimmune diseases. äGene Therapy Induces Antigen-Specific Tolerance in Experimental Collag(epmc).pdf DeepDyve Pubget Overpricing