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10.1371/journal.pone.0154516 http://scihub22266oqcxt.onion/10.1371/journal.pone.0154516 C4861274!4861274!27159038     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2016 ; 11 (5): ä Nephropedia Template TP {{tp|p=27159038|t=2016. Immune Inflammation and Disease Progression in Idiopathic Pulmonary Fibrosis |pdf=|usr=}}{{27159038}} gab.com Text Immune Inflammation and Disease Progression in Idiopathic Pulmonary Fibrosis JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27159038 #FOAvip The clinical course in idiopathic pulmonary fibrosis (IPF) is highly heterogeneous, with some patients having a slow progression and others an accelerated clinical and functional decline. This study aims to clinically characterize the type of progression in IPF and to investigate the pathological basis that might account for the observed differences in disease behavior. Clinical and functional data were analyzed in 73 IPF patients, followed long-time as candidates for lung transplantation. The forced vital capacity (FVC) change/year (< or ?10% predicted) was used to define ?slow? or ?rapid? disease progression. Pathological abnormalities were quantified in the explanted lung of 41 out of 73 patients undergoing lung transplantation. At diagnosis, slow progressors (n = 48) showed longer duration of symptoms and lower FVC than rapid progressors (n = 25). Eleven slow and 3 rapid progressors developed an acute exacerbation (AE) during follow-up. Quantitative lung pathology showed a severe innate and adaptive inflammatory infiltrate in rapid progressors, markedly increased compared to slow progressors and similar to that observed in patients experiencing AE. The extent of inflammation was correlated with the yearly FVC decline (r = 0.52, p = 0.005). In conclusion an innate and adaptive inflammation appears to be a prominent feature in the lung of patients with IPF and could contribute to determining of the rate of disease progression. Twit Text FOAVip Immune Inflammation and Disease Progression in Idiopathic Pulmonary Fibrosis ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27159038 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27159038 #FOAvip English Wikipedia <ref>{{Cite pmid|27159038}}</ref> Immune Inflammation and Disease Progression in Idiopathic Pulmonary Fibrosis #MMPMID27159038 Balestro E; Calabrese F; Turato G; Lunardi F; Bazzan E; Marulli G; Biondini D; Rossi E; Sanduzzi A; Rea F; Rigobello C; Gregori D; Baraldo S; Spagnolo P; Cosio MG; Saetta M PLoS One 2016[]; 11 (5): ä PMID27159038show ga The clinical course in idiopathic pulmonary fibrosis (IPF) is highly heterogeneous, with some patients having a slow progression and others an accelerated clinical and functional decline. This study aims to clinically characterize the type of progression in IPF and to investigate the pathological basis that might account for the observed differences in disease behavior. Clinical and functional data were analyzed in 73 IPF patients, followed long-time as candidates for lung transplantation. The forced vital capacity (FVC) change/year (< or ?10% predicted) was used to define ?slow? or ?rapid? disease progression. Pathological abnormalities were quantified in the explanted lung of 41 out of 73 patients undergoing lung transplantation. At diagnosis, slow progressors (n = 48) showed longer duration of symptoms and lower FVC than rapid progressors (n = 25). Eleven slow and 3 rapid progressors developed an acute exacerbation (AE) during follow-up. Quantitative lung pathology showed a severe innate and adaptive inflammatory infiltrate in rapid progressors, markedly increased compared to slow progressors and similar to that observed in patients experiencing AE. The extent of inflammation was correlated with the yearly FVC decline (r = 0.52, p = 0.005). In conclusion an innate and adaptive inflammation appears to be a prominent feature in the lung of patients with IPF and could contribute to determining of the rate of disease progression. äImmune Inflammation and Disease Progression in Idiopathic Pulmonary Fi(epmc).pdf DeepDyve Pubget Overpricing