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10.1016/j.chom.2016.03.003

http://scihub22266oqcxt.onion/10.1016/j.chom.2016.03.003
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C4861060!4861060!27049583
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suck abstract from ncbi


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pmid27049583      Cell+Host+Microbe 2016 ; 19 (4): 434-41
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  • Intrinsic Defense Mechanisms of the Intestinal Epithelium #MMPMID27049583
  • Ramanan D; Cadwell K
  • Cell Host Microbe 2016[Apr]; 19 (4): 434-41 PMID27049583show ga
  • The intestinal epithelium is a single cell layer that facilitates the absorption of nutrients but also provides a tight barrier to prevent pathogen invasion and dissemination of commensal microbes. Specialized epithelial cells of the gastrointestinal tract achieve this front-line defense by working in concert with lymphoid, myeloid, and stromal cells to secrete an array of factors that limit direct contact between the epithelium and infectious agents. The importance of these mechanisms is underscored by the ability of enteric pathogens to target these mechanisms to achieve invasion and dissemination. This review highlights recent advances in our understanding of these intricate molecular and cellular mechanisms adopted by these cells to promote spatial segregation and barrier maintenance.
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