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10.4196/kjpp.2016.20.3.305 http://scihub22266oqcxt.onion/10.4196/kjpp.2016.20.3.305 C4860373!4860373 !27162485     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27162485 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Korean+J+Physiol+Pharmacol 2016 ; 20 (3 ): 305-14 Nephropedia Template TP {{tp|p=27162485 |t=2016. NecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modulation of the TNF?/Dcn/TGF?1/Smad2 pathway in hypoxia/reoxygenation-treated rat hearts |pdf=|usr=}}{{27162485 }} gab.com Text NecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modulation of the TNF /Dcn/TGF 1/Smad2 pathway in hypoxia/reoxygenation-treated rat hearts JO: Korean J Physiol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27162485 #FOAvip Inflammatory and fibrotic responses are accelerated during the reperfusion period, and excessive fibrosis and inflammation contribute to cardiac malfunction. NecroX compounds have been shown to protect the liver and heart from ischemia-reperfusion injury. The aim of this study was to further define the role and mechanism of action of NecroX-5 in regulating infl ammation and fi brosis responses in a model of hypoxia/reoxygenation (HR). We utilized HR-treated rat hearts and lipopolysaccharide (LPS)-treated H9C2 culture cells in the presence or absence of NecroX-5 (10 µmol/L) treatment as experimental models. Addition of NecroX-5 signifi cantly increased decorin (Dcn) expression levels in HR-treated hearts. In contrast, expression of transforming growth factor beta 1 (TGF?1) and Smad2 phosphorylation (pSmad2) was strongly attenuated in NecroX-5-treated hearts. In addition, signifi cantly increased production of tumor necrosis factor alpha (TNF?), TGF?1, and pSmad2, and markedly decreased Dcn expression levels, were observed in LPS-stimulated H9C2 cells. Interestingly, NecroX-5 supplementation effectively attenuated the increased expression levels of TNF?, TGF?1, and pSmad2, as well as the decreased expression of Dcn. Thus, our data demonstrate potential antiinflammatory and anti-fibrotic effects of NecroX-5 against cardiac HR injuries via modulation of the TNF?/Dcn/TGF?1/Smad2 pathway. Twit Text FOAVip NecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modulation of the TNF /Dcn/TGF 1/Smad2 pathway in hypoxia/reoxygenation-treated rat hearts ????Korean J Physiol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27162485 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27162485 #FOAvip English Wikipedia <ref>{{Cite pmid|27162485 }}</ref> NecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modulation of the TNF?/Dcn/TGF?1/Smad2 pathway in hypoxia/reoxygenation-treated rat hearts #MMPMID27162485 Thu VT ; Kim HK ; Long le T ; Thuy TT ; Huy NQ ; Kim SH ; Kim N ; Ko KS ; Rhee BD ; Han J Korean J Physiol Pharmacol 2016[May]; 20 (3 ): 305-14 PMID27162485 show ga Inflammatory and fibrotic responses are accelerated during the reperfusion period, and excessive fibrosis and inflammation contribute to cardiac malfunction. NecroX compounds have been shown to protect the liver and heart from ischemia-reperfusion injury. The aim of this study was to further define the role and mechanism of action of NecroX-5 in regulating infl ammation and fi brosis responses in a model of hypoxia/reoxygenation (HR). We utilized HR-treated rat hearts and lipopolysaccharide (LPS)-treated H9C2 culture cells in the presence or absence of NecroX-5 (10 µmol/L) treatment as experimental models. Addition of NecroX-5 signifi cantly increased decorin (Dcn) expression levels in HR-treated hearts. In contrast, expression of transforming growth factor beta 1 (TGF?1) and Smad2 phosphorylation (pSmad2) was strongly attenuated in NecroX-5-treated hearts. In addition, signifi cantly increased production of tumor necrosis factor alpha (TNF?), TGF?1, and pSmad2, and markedly decreased Dcn expression levels, were observed in LPS-stimulated H9C2 cells. Interestingly, NecroX-5 supplementation effectively attenuated the increased expression levels of TNF?, TGF?1, and pSmad2, as well as the decreased expression of Dcn. Thus, our data demonstrate potential antiinflammatory and anti-fibrotic effects of NecroX-5 against cardiac HR injuries via modulation of the TNF?/Dcn/TGF?1/Smad2 pathway. äNecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modula(epmc).pdf DeepDyve Pubget Overpricing