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10.4196/kjpp.2016.20.3.297 http://scihub22266oqcxt.onion/10.4196/kjpp.2016.20.3.297 C4860372!4860372!27162484     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Korean+J+Physiol+Pharmacol 2016 ; 20 (3): 297-304 Nephropedia Template TP {{tp|p=27162484|t=2016. Klotho plays a critical role in clear cell renal cell carcinoma progression and clinical outcome |pdf=|usr=}}{{27162484}} gab.com Text Klotho plays a critical role in clear cell renal cell carcinoma progression and clinical outcome JO: Korean J Physiol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27162484 #FOAvip Klotho functions as a tumor suppressor predominantly expressed in renal tubular cells, the origin of clear cell renal cell carcinoma (ccRCC). Altered expression and/or activity of growth factor receptor have been implicated in ccRCC development. Although Klotho suppresses a tumor progression through growth factor receptor signaling including insulin-like growth factor-1 receptor (IGF-1R), the role of Klotho acting on IGF-1R in ccRCC and its clinical relevance remains obscure. Here, we show that Klotho is favorable prognostic factor for ccRCC and exerts tumor suppressive role for ccRCC through inhibiting IGF-1R signaling. Our data shows the following key findings. First, in tumor tissues, the level of Klotho and IGF-1R expression are low or high, respectively, compared to that of adjacent non-neoplastic parenchyma. Second, the Klotho expression is clearly low in higher grade of ccRCC and is closely associated with clinical outcomes in tumor progression. Third, Klotho suppresses IGF-1-stimulated cell proliferation and migration by inhibiting PI3K/Akt pathway. These results provide compelling evidence supporting that Klotho acting on IGF-1R signaling functions as tumor suppressor in ccRCC and suggest that Klotho is a potential carcinostatis substance for ccRCC. Twit Text FOAVip Klotho plays a critical role in clear cell renal cell carcinoma progression and clinical outcome ????Korean J Physiol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27162484 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27162484 #FOAvip English Wikipedia <ref>{{Cite pmid|27162484}}</ref> Klotho plays a critical role in clear cell renal cell carcinoma progression and clinical outcome #MMPMID27162484 Kim JH; Hwang KH; Lkhagvadorj S; Jung JH; Chung HC; Park KS; Kong ID; Eom M; Cha SK Korean J Physiol Pharmacol 2016[May]; 20 (3): 297-304 PMID27162484show ga Klotho functions as a tumor suppressor predominantly expressed in renal tubular cells, the origin of clear cell renal cell carcinoma (ccRCC). Altered expression and/or activity of growth factor receptor have been implicated in ccRCC development. Although Klotho suppresses a tumor progression through growth factor receptor signaling including insulin-like growth factor-1 receptor (IGF-1R), the role of Klotho acting on IGF-1R in ccRCC and its clinical relevance remains obscure. Here, we show that Klotho is favorable prognostic factor for ccRCC and exerts tumor suppressive role for ccRCC through inhibiting IGF-1R signaling. Our data shows the following key findings. First, in tumor tissues, the level of Klotho and IGF-1R expression are low or high, respectively, compared to that of adjacent non-neoplastic parenchyma. Second, the Klotho expression is clearly low in higher grade of ccRCC and is closely associated with clinical outcomes in tumor progression. Third, Klotho suppresses IGF-1-stimulated cell proliferation and migration by inhibiting PI3K/Akt pathway. These results provide compelling evidence supporting that Klotho acting on IGF-1R signaling functions as tumor suppressor in ccRCC and suggest that Klotho is a potential carcinostatis substance for ccRCC. äKlotho plays a critical role in clear cell renal cell carcinoma progre(epmc).pdf DeepDyve Pubget Overpricing