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2016 ; 20
(3
): 261-8
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Immunotherapy with methyl gallate, an inhibitor of Treg cell migration, enhances
the anti-cancer effect of cisplatin therapy
#MMPMID27162480
Kim H
; Lee G
; Sohn SH
; Lee C
; Kwak JW
; Bae H
Korean J Physiol Pharmacol
2016[May]; 20
(3
): 261-8
PMID27162480
show ga
Foxp3(+) CD25(+)CD4(+) regulatory T (Treg) cells are crucial for the maintenance
of immunological self-tolerance and are abundant in tumors. Most of these cells
are chemo-attracted to tumor tissues and suppress anti-tumor responses inside the
tumor. Currently, several cancer immunotherapies targeting Treg cells are being
clinically tested. Cisplatin is one of the most potent chemotherapy drugs widely
used for cancer treatment. While cisplatin is a powerful drug for the treatment
of multiple cancers, there are obstacles that limit its use, such as renal
dysfunction and the development of cisplatin-resistant cancer cells after its
use. To minimize these barriers, combinatorial therapies of cisplatin with other
drugs have been developed and have proven to be more effective to treat cancer.
In the present study, we evaluated the eff ect of the combination therapy using
methyl gallate with cisplatin in EL4 murine lymphoma bearing C57BL/6 mice. The
combinatorial therapy of methyl gallate and cisplatin showed stronger anti-cancer
eff ects than methyl gallate or cisplatin as single treatments. In Treg
cell-depleted mice, however, the eff ect of methyl gallate vanished. It was found
that methyl gallate treatment inhibited Treg cell migration into the tumor
regardless of cisplatin treatment. Additionally, in both the normal and
cisplatin-treated tumor-bearing mice, there was no renal toxicity attributed to
methyl gallate treatment. These findings suggest that methyl gallate treatment
could be useful as an adjuvant method accompanied with cisplatin therapy.
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