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2015 ; 9350
(ä): 230-237
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Topography-Based Registration of Developing Cortical Surfaces in Infants Using
Multidirectional Varifold Representation
#MMPMID27169137
Rekik I
; Li G
; Lin W
; Shen D
Med Image Comput Comput Assist Interv
2015[Oct]; 9350
(ä): 230-237
PMID27169137
show ga
Cortical surface registration or matching facilitates atlasing, cortical
morphology-function comparison and statistical analysis. Methods that
geodesically shoot surfaces into one another, as currents or varifolds, provide
an elegant mathematical framework for generic surface matching and dynamic local
features estimation, such as deformation momenta. However, conventional current
and varifold matching methods only use the normals of the surface to measure its
geometry and guide the warping process, which overlooks the importance of the
direction in the convoluted cortical sulcal and gyral folds. To cope with the
stated limitation, we decompose each cortical surface into its normal and tangent
varifold representations, by integrating principal curvature direction field into
the varifold matching framework, thus providing rich information for the
direction of cortical folding and better characterization of the cortical
geometry. To include more informative cortical geometric features in the matching
process, we adaptively place control points based on the surface topography,
hence the deformation is controlled by points lying on gyral crests (or "hills")
and sulcal fundi (or "valleys") of the cortical surface, which are the most
reliable and important topographic and anatomical landmarks on the cortex. We
applied our method for registering the developing cortical surfaces in 12 infants
from 0 to 6 months of age. Both of these variants significantly improved the
matching accuracy in terms of closeness to the target surface and the precision
of alignment with regional anatomical boundaries, when compared with several
state-of-the-art methods: (1) diffeomorphic spectral matching, (2) current-based
surface matching and (3) original varifold-based surface matching.