Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27169139
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27169139
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Med+Image+Comput+Comput+Assist+Interv
2015 ; 9351
(ä): 543-550
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Parcellation of Infant Surface Atlas Using Developmental Trajectories of
Multidimensional Cortical Attributes
#MMPMID27169139
Li G
; Wang L
; Gilmore JH
; Lin W
; Shen D
Med Image Comput Comput Assist Interv
2015[Oct]; 9351
(ä): 543-550
PMID27169139
show ga
Cortical surface atlases, equipped with anatomically and functionally defined
parcellations, are of fundamental importance in neuroimaging studies. Typically,
parcellations of surface atlases are derived based on the sulcal-gyral landmarks,
which are extremely variable across individuals and poorly matched with
microstructural and functional boundaries. Cortical developmental trajectories in
infants reflect underlying changes of microstructures, which essentially
determines the molecular organization and functional principles of the cortex,
thus allowing better definition of developmentally, microstructurally, and
functionally distinct regions, compared to conventional sulcal-gyral landmarks.
Accordingly, a parcellation of infant cortical surface atlas was proposed, based
on the developmental trajectories of cortical thickness in infants, revealing
regional patterning of cortical growth. However, cortical anatomy is jointly
characterized by biologically-distinct, multidimensional cortical attributes,
i.e., cortical thickness, surface area, and local gyrification, each with its
distinct genetic underpinning, cellular mechanism, and developmental
trajectories. To date, the parcellations based on the development of surface area
and local gyrification is still missing. To bridge this critical gap, for the
first time, we parcellate an infant cortical surface atlas into distinct regions
based solely on developmental trajectories of surface area and local
gyrification, respectively. For each cortical attribute, we first nonlinearly
fuse the subject-specific similarity matrices of vertices' developmental
trajectories of all subjects into a single matrix, which helps better capture
common and complementary information of the population than the conventional
method of simple averaging of all subjects' matrices. Then, we perform spectral
clustering based on this fused matrix. We have applied our method to parcellate
an infant surface atlas using the developmental trajectories of surface area and
local gyrification from 35 healthy infants, each with up to 7 time points in the
first two postnatal years, revealing biologically more meaningful growth
patterning than the conventional method.