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10.1016/j.stem.2016.03.002 http://scihub22266oqcxt.onion/10.1016/j.stem.2016.03.002 C4860147!4860147 !27053300     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27053300 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Stem+Cell 2016 ; 18 (5 ): 668-81 Nephropedia Template TP {{tp|p=27053300 |t=2016. TGF-? Inhibition Rescues Hematopoietic Stem Cell Defects and Bone Marrow Failure in Fanconi Anemia |pdf=|usr=}}{{27053300 }} gab.com Text TGF- Inhibition Rescues Hematopoietic Stem Cell Defects and Bone Marrow Failure in Fanconi Anemia JO: Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=27053300 #FOAvip Fanconi anemia (FA) is an inherited DNA repair disorder characterized by progressive bone marrow failure (BMF) from hematopoietic stem and progenitor cell (HSPC) attrition. A greater understanding of the pathogenesis of BMF could improve the therapeutic options for FA patients. Using a genome-wide shRNA screen in human FA fibroblasts, we identify transforming growth factor-? (TGF-?) pathway-mediated growth suppression as a cause of BMF in FA. Blocking the TGF-? pathway improves the survival of FA cells and rescues the proliferative and functional defects of HSPCs derived from FA mice and FA patients. Inhibition of TGF-? signaling in FA HSPCs results in elevated homologous recombination (HR) repair with a concomitant decrease in non-homologous end-joining (NHEJ), accounting for the improvement in cellular growth. Together, our results suggest that elevated TGF-? signaling contributes to BMF in FA by impairing HSPC function and may be a potential therapeutic target for the treatment of FA. Twit Text FOAVip TGF- Inhibition Rescues Hematopoietic Stem Cell Defects and Bone Marrow Failure in Fanconi Anemia ????Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=27053300 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27053300 #FOAvip English Wikipedia <ref>{{Cite pmid|27053300 }}</ref> TGF-? Inhibition Rescues Hematopoietic Stem Cell Defects and Bone Marrow Failure in Fanconi Anemia #MMPMID27053300 Zhang H ; Kozono DE ; O'Connor KW ; Vidal-Cardenas S ; Rousseau A ; Hamilton A ; Moreau L ; Gaudiano EF ; Greenberger J ; Bagby G ; Soulier J ; Grompe M ; Parmar K ; D'Andrea AD Cell Stem Cell 2016[May]; 18 (5 ): 668-81 PMID27053300 show ga Fanconi anemia (FA) is an inherited DNA repair disorder characterized by progressive bone marrow failure (BMF) from hematopoietic stem and progenitor cell (HSPC) attrition. A greater understanding of the pathogenesis of BMF could improve the therapeutic options for FA patients. Using a genome-wide shRNA screen in human FA fibroblasts, we identify transforming growth factor-? (TGF-?) pathway-mediated growth suppression as a cause of BMF in FA. Blocking the TGF-? pathway improves the survival of FA cells and rescues the proliferative and functional defects of HSPCs derived from FA mice and FA patients. Inhibition of TGF-? signaling in FA HSPCs results in elevated homologous recombination (HR) repair with a concomitant decrease in non-homologous end-joining (NHEJ), accounting for the improvement in cellular growth. Together, our results suggest that elevated TGF-? signaling contributes to BMF in FA by impairing HSPC function and may be a potential therapeutic target for the treatment of FA. |Acetaldehyde/toxicity [MESH] |Animals [MESH] |Bone Marrow/*pathology [MESH] |Cell Survival/drug effects [MESH] |DNA End-Joining Repair/drug effects [MESH] |Down-Regulation/drug effects [MESH] |Fanconi Anemia/*pathology [MESH] |Hematopoietic Stem Cells/drug effects/*pathology [MESH] |Homologous Recombination/genetics [MESH] |Humans [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mutagens/toxicity [MESH] |Signal Transduction/drug effects [MESH] |Stress, Physiological/drug effects [MESH] |Transforming Growth Factor beta/*antagonists & inhibitors/metabolism [MESH]TGF-? Inhibition Rescues Hematopoietic Stem Cell Defects and Bone Marr(epmc).pdf DeepDyve Pubget Overpricing