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10.1007/s00109-016-1391-6

http://scihub22266oqcxt.onion/10.1007/s00109-016-1391-6
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C4860114!4860114!26923718
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suck abstract from ncbi

pmid26923718      J+Mol+Med+(Berl) 2016 ; 94 (5): 523-34
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  • Biological and Pathological Activities of Interleukin-22 #MMPMID26923718
  • Lanfranca MP; Lin Y; Fang J; Zou W; Frankel T
  • J Mol Med (Berl) 2016[May]; 94 (5): 523-34 PMID26923718show ga
  • Interleukin (IL)-22, a member of the IL-10 family, is a cytokine secreted by several types of immune cells including IL-22+CD4+ T cells (Th22) and IL-22 expressing innate leukocytes (ILC22). Recent studies have demonstrated that IL-22 is a key component in mucosal barrier defense, tissue repair, epithelial cell survival and proliferation. Furthermore, accumulating evidence has defined both protective and pathogenic properties of IL-22 in a number of conditions including autoimmune disease, infection and malignancy. In this Review we summarize the expression and signaling pathway and functional characteristics of the IL-22 and IL-22 receptor axis in physiological and pathological scenarios, and discuss the potential to target IL-22 signaling to treat human diseases.
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