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10.1038/nm.4068 http://scihub22266oqcxt.onion/10.1038/nm.4068 C4860105!4860105!27019327     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Med 2016 ; 22 (5): 516-23 Nephropedia Template TP {{tp|p=27019327|t=2016. Commensal microbiota affects ischemic stroke outcome by regulating intestinal ??T cells |pdf=|usr=}}{{27019327}} gab.com Text Commensal microbiota affects ischemic stroke outcome by regulating intestinal T cells JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=27019327 #FOAvip Commensal gut bacteria impact the host immune system and can influence disease processes in several organs, including the brain. However, it remains unclear whether the microbiota has an impact on the outcome of acute brain injury. Here we show that antibiotic-induced alterations in the intestinal flora reduces ischemic brain injury in mice, an effect transmissible by fecal transplants. Intestinal dysbiosis alters immune homeostasis in the small intestine leading to an increase in regulatory T cells and a reduction in IL-17+ ?? T cells, through altered dendritic cell activity. Dysbiosis suppresses trafficking of effector T cells from the gut to the leptomeninges after stroke. Interleukin-10 (IL-10) and IL-17 are required for the neuroprotection afforded by intestinal dysbiosis. The findings reveal a previously unrecognized gut-brain axis and the impact of the intestinal flora and meningeal IL-17+ ?? T cells on ischemic injury. Twit Text FOAVip Commensal microbiota affects ischemic stroke outcome by regulating intestinal T cells ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=27019327 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27019327 #FOAvip English Wikipedia <ref>{{Cite pmid|27019327}}</ref> Commensal microbiota affects ischemic stroke outcome by regulating intestinal ??T cells #MMPMID27019327 Benakis C; Brea D; Caballero S; Faraco G; Moore J; Murphy M; Sita G; Racchumi G; Ling L; Pamer EG; Iadecola C; Anrather J Nat Med 2016[May]; 22 (5): 516-23 PMID27019327show ga Commensal gut bacteria impact the host immune system and can influence disease processes in several organs, including the brain. However, it remains unclear whether the microbiota has an impact on the outcome of acute brain injury. Here we show that antibiotic-induced alterations in the intestinal flora reduces ischemic brain injury in mice, an effect transmissible by fecal transplants. Intestinal dysbiosis alters immune homeostasis in the small intestine leading to an increase in regulatory T cells and a reduction in IL-17+ ?? T cells, through altered dendritic cell activity. Dysbiosis suppresses trafficking of effector T cells from the gut to the leptomeninges after stroke. Interleukin-10 (IL-10) and IL-17 are required for the neuroprotection afforded by intestinal dysbiosis. The findings reveal a previously unrecognized gut-brain axis and the impact of the intestinal flora and meningeal IL-17+ ?? T cells on ischemic injury. äCommensal microbiota affects ischemic stroke outcome by regulating int(epmc).pdf DeepDyve Pubget Overpricing