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NPGPx (GPx7): a novel oxidative stress sensor/transmitter with multiple roles in redox homeostasis |pdf=|usr=}}{{27186289 }} gab.com Text NPGPx (GPx7): a novel oxidative stress sensor/transmitter with multiple roles in redox homeostasis JO: Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=27186289 #FOAvip NPGPx (GPx7) is a member of the glutathione peroxidase (GPx) family without any GPx activity. GPx7 displays a unique function which serves as a stress sensor/transmitter to transfer the signal to its interacting proteins by shuttling disulfide bonds in response to various stresses. In this review, we focus on the exceptional structural and biochemical features of GPx7 compared to other 7 family members and described how GPx7 regulates the diverse signaling targets including GRP78, PDI, CPEB2, and XRN2, and their different roles in unfolded protein response, oxidative stress, and non-targeting siRNA stress response, respectively. The phenotypes associated with GPx7 deficiency in mouse or human including ROS accumulations, highly elevated cancer incidences, auto-immune disorders, and obesity are also revealed in this paper. Finally, we compare GPx8 with GPx7, which shares the highest structural similarity but different biological roles in stress response. These insights have thus provided a more comprehensive understanding of the role of GPx7 in the maintenance of redox homeostasis. Twit Text FOAVip NPGPx (GPx7): a novel oxidative stress sensor/transmitter with multiple roles in redox homeostasis ????Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=27186289 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27186289 #FOAvip English Wikipedia <ref>{{Cite pmid|27186289 }}</ref> NPGPx (GPx7): a novel oxidative stress sensor/transmitter with multiple roles in redox homeostasis #MMPMID27186289 Chen YI ; Wei PC ; Hsu JL ; Su FY ; Lee WH Am J Transl Res 2016[]; 8 (4 ): 1626-40 PMID27186289 show ga NPGPx (GPx7) is a member of the glutathione peroxidase (GPx) family without any GPx activity. GPx7 displays a unique function which serves as a stress sensor/transmitter to transfer the signal to its interacting proteins by shuttling disulfide bonds in response to various stresses. In this review, we focus on the exceptional structural and biochemical features of GPx7 compared to other 7 family members and described how GPx7 regulates the diverse signaling targets including GRP78, PDI, CPEB2, and XRN2, and their different roles in unfolded protein response, oxidative stress, and non-targeting siRNA stress response, respectively. The phenotypes associated with GPx7 deficiency in mouse or human including ROS accumulations, highly elevated cancer incidences, auto-immune disorders, and obesity are also revealed in this paper. Finally, we compare GPx8 with GPx7, which shares the highest structural similarity but different biological roles in stress response. These insights have thus provided a more comprehensive understanding of the role of GPx7 in the maintenance of redox homeostasis. äNPGPx (GPx7): a novel oxidative stress sensor/transmitter with multipl(epmc).pdf DeepDyve Pubget Overpricing