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http://scihub22266oqcxt.onion/ C4859876!4859876!27186320     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Physiol+Pathophysiol+Pharmacol 2016 ; 8 (1): 28-34 Nephropedia Template TP {{tp|p=27186320|t=2016. Role of autophagy in megakaryocyte differentiation and platelet formation |pdf=|usr=}}{{27186320}} gab.com Text Role of autophagy in megakaryocyte differentiation and platelet formation JO: Int J Physiol Pathophysiol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27186320 #FOAvip Autophagy is a conserved biological process for digestion and recycling of cytoplasmic constituents in eukaryotic cells. Autophagy may trigger cell death or promote cell survival following various forms of stress. The emerging roles of autophagy in megakaryopoiesis, thrombopoiesis, and platelet function have been uncovered using not only in vitro and in vivo genetic models, but also in clinical observations of autophagic structure in patients with thrombocytopenic disorders. Inhibition of autophagy in early stage of megakaryocyte differentiation appears to impede megakaryocyte maturation, reduce platelet formation, and affect platelet function, whereas autophagic deficiency in mature megakaryocytes gives rise to abnormal platelet activation and function without changing platelet size and number. On the other hand, induction of autophagy by rapamycin in megakaryocytes exhibited substantial therapeutic benefits in patients with immune thrombocytopenic purpura (ITP). This mini-review is to highlight recent progresses in understanding the regulation of autophagy in megakaryopoiesis, thrombopoiesis and platelet function to bridge the gap between autophagy and megakaryocyte/platelet pathophysiology. Twit Text FOAVip Role of autophagy in megakaryocyte differentiation and platelet formation ????Int J Physiol Pathophysiol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27186320 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27186320 #FOAvip English Wikipedia <ref>{{Cite pmid|27186320}}</ref> Role of autophagy in megakaryocyte differentiation and platelet formation #MMPMID27186320 You T; Wang Q; Zhu L Int J Physiol Pathophysiol Pharmacol 2016[]; 8 (1): 28-34 PMID27186320show ga Autophagy is a conserved biological process for digestion and recycling of cytoplasmic constituents in eukaryotic cells. Autophagy may trigger cell death or promote cell survival following various forms of stress. The emerging roles of autophagy in megakaryopoiesis, thrombopoiesis, and platelet function have been uncovered using not only in vitro and in vivo genetic models, but also in clinical observations of autophagic structure in patients with thrombocytopenic disorders. Inhibition of autophagy in early stage of megakaryocyte differentiation appears to impede megakaryocyte maturation, reduce platelet formation, and affect platelet function, whereas autophagic deficiency in mature megakaryocytes gives rise to abnormal platelet activation and function without changing platelet size and number. On the other hand, induction of autophagy by rapamycin in megakaryocytes exhibited substantial therapeutic benefits in patients with immune thrombocytopenic purpura (ITP). This mini-review is to highlight recent progresses in understanding the regulation of autophagy in megakaryopoiesis, thrombopoiesis and platelet function to bridge the gap between autophagy and megakaryocyte/platelet pathophysiology. äRole of autophagy in megakaryocyte differentiation and platelet format(epmc).pdf DeepDyve Pubget Overpricing