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10.7554/eLife.13758 http://scihub22266oqcxt.onion/10.7554/eLife.13758 C4859801!4859801!27077952     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       eLife 2016 ; 5 (ä): ä Nephropedia Template TP {{tp|p=27077952|t=2016. The Apelin receptor enhances Nodal/TGF? signaling to ensure proper cardiac development |pdf=|usr=}}{{27077952}} gab.com Text The Apelin receptor enhances Nodal/TGF signaling to ensure proper cardiac development JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=27077952 #FOAvip The Apelin receptor (Aplnr) is essential for heart development, controlling the early migration of cardiac progenitors. Here we demonstrate that in zebrafish Aplnr modulates Nodal/TGF? signaling, a key pathway essential for mesendoderm induction and migration. Loss of Aplnr function leads to a reduction in Nodal target gene expression whereas activation of Aplnr by a non-peptide agonist increases the expression of these same targets. Furthermore, loss of Aplnr results in a delay in the expression of the cardiogenic transcription factors mespaa/ab. Elevating Nodal levels in aplnra/b morphant and double mutant embryos is sufficient to rescue cardiac differentiation defects. We demonstrate that loss of Aplnr attenuates the activity of a point source of Nodal ligands Squint and Cyclops in a non-cell autonomous manner. Our results favour a model in which Aplnr is required to fine-tune Nodal output, acting as a specific rheostat for the Nodal/TGF? pathway during the earliest stages of cardiogenesis.DOI:http://dx.doi.org/10.7554/eLife.13758.001 Twit Text FOAVip The Apelin receptor enhances Nodal/TGF signaling to ensure proper cardiac development ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=27077952 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27077952 #FOAvip English Wikipedia <ref>{{Cite pmid|27077952}}</ref> The Apelin receptor enhances Nodal/TGF? signaling to ensure proper cardiac development #MMPMID27077952 Deshwar AR; Chng SC; Ho L; Reversade B; Scott IC eLife 2016[]; 5 (ä): ä PMID27077952show ga The Apelin receptor (Aplnr) is essential for heart development, controlling the early migration of cardiac progenitors. Here we demonstrate that in zebrafish Aplnr modulates Nodal/TGF? signaling, a key pathway essential for mesendoderm induction and migration. Loss of Aplnr function leads to a reduction in Nodal target gene expression whereas activation of Aplnr by a non-peptide agonist increases the expression of these same targets. Furthermore, loss of Aplnr results in a delay in the expression of the cardiogenic transcription factors mespaa/ab. Elevating Nodal levels in aplnra/b morphant and double mutant embryos is sufficient to rescue cardiac differentiation defects. We demonstrate that loss of Aplnr attenuates the activity of a point source of Nodal ligands Squint and Cyclops in a non-cell autonomous manner. Our results favour a model in which Aplnr is required to fine-tune Nodal output, acting as a specific rheostat for the Nodal/TGF? pathway during the earliest stages of cardiogenesis.DOI:http://dx.doi.org/10.7554/eLife.13758.001 äThe Apelin receptor enhances Nodal/TGF? signaling to ensure proper car(epmc).pdf DeepDyve Pubget Overpricing