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10.4062/biomolther.2015.160 http://scihub22266oqcxt.onion/10.4062/biomolther.2015.160 C4859787!4859787!27133258     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomol+Ther+(Seoul) 2016 ; 24 (3): 244-51 Nephropedia Template TP {{tp|p=27133258|t=2016. Blockade of STAT3 in T Cells Inhibits Germinal Center Reactions against Intranasal Allergens |pdf=|usr=}}{{27133258}} gab.com Text Blockade of STAT3 in T Cells Inhibits Germinal Center Reactions against Intranasal Allergens JO: Biomol Ther (Seoul) http://www.kidney.de/pget.php?&tw=1&pmid=27133258 #FOAvip Understanding the developmental mechanisms of humoral immunity against intranasal antigens is essential for the development of therapeutic approaches against air-borne pathogens as well as allergen-induced pulmonary inflammation. Follicular helper T (Tfh) cells expressing CXCR5 are required for humoral immunity by providing IL-21 and ICOS costimulation to activated B cells. However, the regulation of Tfh cell responses against intranasal antigens remains unclear. Here, we found that the generation of Tfh cells and germinal center B cells in the bronchial lymph node against intranasal proteinase antigens was independent of TGF-?. In contrast, administration of STAT3 inhibitor STA-21 suppressed the generation of Tfh cells and germinal center B cells. Compared with wild-type OT-II T cells, STAT3-deficient OT-II T cells transferred into recipients lacking T cells not only showed significantly reduced frequency Tfh cells, but also induced diminished IgG as well as IgE specific for the intranasal antigens. Co-transfer study of wild-type OT-II and STAT3-deficient OT-II T cells revealed that the latter failed to differentiate into Tfh cells. These findings demonstrate that T cell-intrinsic STAT3 is required for the generation of Tfh cells to intranasal antigens and that targeting STAT3 might be an effective approach to ameliorate antibody-mediated pathology in the lung. Twit Text FOAVip Blockade of STAT3 in T Cells Inhibits Germinal Center Reactions against Intranasal Allergens ????Biomol Ther (Seoul) http://www.kidney.de/pget.php?&tw=1&pmid=27133258 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27133258 #FOAvip English Wikipedia <ref>{{Cite pmid|27133258}}</ref> Blockade of STAT3 in T Cells Inhibits Germinal Center Reactions against Intranasal Allergens #MMPMID27133258 Choi G; Chung Y Biomol Ther (Seoul) 2016[May]; 24 (3): 244-51 PMID27133258show ga Understanding the developmental mechanisms of humoral immunity against intranasal antigens is essential for the development of therapeutic approaches against air-borne pathogens as well as allergen-induced pulmonary inflammation. Follicular helper T (Tfh) cells expressing CXCR5 are required for humoral immunity by providing IL-21 and ICOS costimulation to activated B cells. However, the regulation of Tfh cell responses against intranasal antigens remains unclear. Here, we found that the generation of Tfh cells and germinal center B cells in the bronchial lymph node against intranasal proteinase antigens was independent of TGF-?. In contrast, administration of STAT3 inhibitor STA-21 suppressed the generation of Tfh cells and germinal center B cells. Compared with wild-type OT-II T cells, STAT3-deficient OT-II T cells transferred into recipients lacking T cells not only showed significantly reduced frequency Tfh cells, but also induced diminished IgG as well as IgE specific for the intranasal antigens. Co-transfer study of wild-type OT-II and STAT3-deficient OT-II T cells revealed that the latter failed to differentiate into Tfh cells. These findings demonstrate that T cell-intrinsic STAT3 is required for the generation of Tfh cells to intranasal antigens and that targeting STAT3 might be an effective approach to ameliorate antibody-mediated pathology in the lung. äBlockade of STAT3 in T Cells Inhibits Germinal Center Reactions agains(epmc).pdf DeepDyve Pubget Overpricing