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10.1038/onc.2014.355 http://scihub22266oqcxt.onion/10.1038/onc.2014.355 C4859767!4859767!25362851     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncogene 2015 ; 34 (32): 4229-37 Nephropedia Template TP {{tp|p=25362851|t=2015. Manganese superoxide dismutase deficiency triggers mitochondrial uncoupling and the Warburg effect |pdf=|usr=}}{{25362851}} gab.com Text Manganese superoxide dismutase deficiency triggers mitochondrial uncoupling and the Warburg effect JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=25362851 #FOAvip Manganese superoxide dismutase (MnSOD) is a mitochondrially localized primary antioxidant enzyme, known to be essential for the survival of aerobic life and to play important roles in tumorigenesis. Here, we show that MnSOD deficiency in skin tissues of MnSOD-heterozygous knockout (Sod2+/?) mice leads to increased expresson of uncoupling proteins (UCPs). When MnSOD is deficient, superoxide radical and its resulting reactive oxygen species (ROS) activate ligand binding to peroxisome proliferator-activated receptor alpha (PPAR?), suggesting that the activation of PPAR? signaling is a major mechanism underlying MnSOD-dependent UCPs expression that consequently triggers the PI3K/Akt/mTOR pathway, leading to increased aerobic glycolysis. Knockdown of UCPs and mTOR suppresses lactate production and increases ATP levels, suggesting that UCPs contribute to increased glycolysis. These results highlight the existence of a free radical-mediated mechanism that activates mitochondria uncoupling to reduce ROS production, which precedes the glycolytic adaptation described as the Warburg Effect. Twit Text FOAVip Manganese superoxide dismutase deficiency triggers mitochondrial uncoupling and the Warburg effect ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=25362851 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25362851 #FOAvip English Wikipedia <ref>{{Cite pmid|25362851}}</ref> Manganese superoxide dismutase deficiency triggers mitochondrial uncoupling and the Warburg effect #MMPMID25362851 Xu Y; Miriyala S; Fang F; Bakthavatchalu V; Noel T; Schnell D; Wang C; St Clair WH; St Clair DK Oncogene 2015[Aug]; 34 (32): 4229-37 PMID25362851show ga Manganese superoxide dismutase (MnSOD) is a mitochondrially localized primary antioxidant enzyme, known to be essential for the survival of aerobic life and to play important roles in tumorigenesis. Here, we show that MnSOD deficiency in skin tissues of MnSOD-heterozygous knockout (Sod2+/?) mice leads to increased expresson of uncoupling proteins (UCPs). When MnSOD is deficient, superoxide radical and its resulting reactive oxygen species (ROS) activate ligand binding to peroxisome proliferator-activated receptor alpha (PPAR?), suggesting that the activation of PPAR? signaling is a major mechanism underlying MnSOD-dependent UCPs expression that consequently triggers the PI3K/Akt/mTOR pathway, leading to increased aerobic glycolysis. Knockdown of UCPs and mTOR suppresses lactate production and increases ATP levels, suggesting that UCPs contribute to increased glycolysis. These results highlight the existence of a free radical-mediated mechanism that activates mitochondria uncoupling to reduce ROS production, which precedes the glycolytic adaptation described as the Warburg Effect. äManganese superoxide dismutase deficiency triggers mitochondrial uncou(epmc).pdf DeepDyve Pubget Overpricing